Exploring brain function in autism and food addiction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the neural networks associated with Autism Spectrum Disorder (ASD) and Food Addictive Disorder (FAD) using MRI technology. Participants include adults diagnosed with ASD, those with food addiction, and healthy volunteers for comparison. The research aims to identify common pathophysiological features related to the dysfunction of the reward system in these conditions. By analyzing brain activity through MRI and EEG, the study seeks to enhance understanding of the underlying mechanisms of these disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria)

Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria).

Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk.

For all participants:

* Age greater than or equal to 18 years old
* Without intellectual delay (IQ \> 70).
* Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator.
* Free, express, informed and written consent of the participant.
* Participant affiliated to a social security scheme

Exclusion Criteria:

* Neuromotor disorders.
* Visual disturbances not corrected or incompatible with MRI.
* Known epilepsy.
* Current substance use disorder with emotional distress/significant impact on functional outcome
* Rare genetic syndrome.
* Contraindications to MRI (other than body circumference)
* For women of childbearing age: negative urine or blood pregnancy test
* Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)

Where it's running

• Center-Val de Loire Region Autism Resource Center
  Tours, France Recruiting
• University Addictology Service, Liaison Team and Addictology Care
  Tours, France Recruiting
• University Hospital, Medical Imaging Service
  Tours, France Recruiting

Study contacts

• Principal investigator: Frédéric BRIEND, PhD — University Hospital,Tours -INSERM U1253 iBrain
• Study coordinator: Frédéric BRIEND, PhD
• Email: frederic.briend@univ-tours.fr
• Phone: +33247478519

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.