Exploring brain activity differences in cyclic vomiting syndrome
Official title: Cortical Excitability in Cyclic Vomiting Syndrome
Run by University of Pittsburgh · NCT05256160 · Data updated 2026-11-12
This study is testing how brain activity differs in people with cyclic vomiting syndrome compared to healthy individuals to better understand the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | May 16, 2022 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | August 14, 2026 |
| Trial ID | NCT05256160 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with cyclic vomiting syndrome.
✕Probably not a fit
Patients with a history of CVS who are part of the healthy control population may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This exploratory study aims to assess differences in cortical excitability between patients with cyclic vomiting syndrome (CVS) and healthy controls using Transcranial Magnetic Stimulation (TMS). The study employs a paired-pulse TMS paradigm to evaluate intracortical inhibition and facilitation of cortical circuitry by stimulating the motor cortex and measuring the electromyographic response of a target muscle. Various inter-stimulus intervals will be utilized to analyze different aspects of cortical processing. Additionally, clinical, demographic, and autonomic data will be collected to investigate their impact on cortical excitability measures.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the neurological underpinnings of cyclic vomiting syndrome, potentially leading to improved treatment strategies.
How similar studies have gone: While this approach is exploratory, similar studies using TMS have shown promise in understanding neurological conditions, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of CVS Exclusion Criteria: * history of CVS (for healthy control population only) * psychosis or altered cognitive status * history of head injury, metal in the skull, stroke, or a history of seizures or a history of syncope (fainting or passing out) * implantable devices, such as a pacemaker or nerve stimulator * current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day * pregnancy
Where it's running
-
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: David J Levinthal, MD PhD — University of Pittsburgh
- Study coordinator: Elijah D Wright
- Email: edw87@pitt.edu
- Phone: 412-647-1228
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.