Exploring biomarkers for different types of dementia in various age groups
Exploring Biomarkers in Age Stratified PUMCH Dementia Cohort
This study is trying to find new biological markers for different types of dementia in people of various ages to help improve diagnosis and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT04924361 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify and evaluate biomarkers for dementia by stratifying patients based on age and type of dementia. It involves comprehensive data collection, including clinical history, neuropsychological assessments, and multi-modal neuroimaging techniques. The study also focuses on analyzing various biological samples such as serum, cerebrospinal fluid (CSF), and urine to discover new fluid biomarkers and genetic markers associated with dementia. Patients will be followed up every six months, and autopsy data will be used to validate the findings.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with neurodegenerative dementia who have a fixed caregiver and can participate in regular follow-ups.
Not a fit: Patients who are not diagnosed with dementia, including those with mild cognitive impairment, or those with severe systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and early diagnoses of different types of dementia, improving patient management and treatment outcomes.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for dementia, but this specific age-stratified approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Neurodegenerative dementia diagnosis based on 2011 NIA-AA criteria of Dementia * Fixed care giver and can follow up regularly Exclusion Criteria: * Not demented, including MCI * Systemic severe diseases and severe vision or hearing problem effecting follow up and neuropsychological evaluation * Without fixed care giver * Reject informed consent * Expected life shorter than 2 years
Where this trial is running
Beijing, Beijing
- Peking Union Medical College Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Jing Gao, Doctor — Peking Union Medical College Hospital
- Study coordinator: Chenhui Mao, Doctor
- Email: maochenhui@pumch.cn
- Phone: +86018611895308
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.