Exploring a new therapy approach for depression and anxiety

Feasibility of Process-based Therapy in a Naturalistic Setting

Not applicable Interventional Goethe University · NCT06530888

This study is testing a new therapy approach for depression and anxiety to see if it works better than usual methods when used by therapists in real-life settings.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment60 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorGoethe University Academic / other
Locations1 site (Frankfurt am Main, Hessen)
Trial IDNCT06530888 on ClinicalTrials.gov

What this trial studies

This study investigates the feasibility of Process-based Therapy (PBT) in a natural mental health care setting, where practitioners typically rely on established theories and personal experience for treatment decisions. PBT emphasizes the use of empirical data and rational criteria to tailor interventions, utilizing ecological momentary assessment and dynamic network analysis to inform treatment. The study aims to determine whether PBT can be effectively implemented by psychotherapists and to compare its acceptability and efficacy against routine psychotherapy practices. By focusing on real-world applications, the research seeks to provide insights into the practical use of PBT in treating depressive and anxiety disorders.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-65 with a primary diagnosis of depressive or anxiety disorders who can communicate in German.

Not a fit: Patients with severe mental health issues such as suicidality, substance abuse, or certain personality disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could enhance treatment outcomes for patients with depression and anxiety by providing more personalized and evidence-based therapy options.

How similar studies have performed: While the specific approach of Process-based Therapy is novel, similar studies exploring empirical and individualized treatment methods have shown promise in improving patient outcomes.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* A primary DSM-5 diagnosis of a depressive or anxiety disorder
* Age 18-65 years
* Sufficient knowledge of the German language
* Participating patients are not required to discontinue medication, but to keep medication constant over the treatment period

Exclusion Criteria:

* Increased suicidality
* Substance abuse or dependency
* Diagnose of a cluster A or B (DSM-5) personality disorder
* Pervasive developmental disorder
* Psychotic disorder
* Eating disorder
* Bipolar disorder
* Severe physical illness

Where this trial is running

Frankfurt am Main, Hessen

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Depressive DisorderAnxiety DisorderfeasibilityProcess-based Therapy
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.