Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Expiratory (breathing-out) muscle strength and health outcomes in bronchiectasis

Official title: Effect of Expiratory Muscle Strength on Hospital Admission, Disease Severity and Quality of Life in Patients With Bronchiectasis

Run by Saglik Bilimleri Universitesi · NCT07104942 · Data updated 2026-11-12

This project tests whether weaker expiratory (breathing-out) muscles are linked to worse symptoms, more hospital visits, and lower quality of life in adults with non‑cystic fibrosis bronchiectasis.

More Bronchiectasis trials

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment64 (estimated)
SponsorSaglik Bilimleri Universitesi
Academic / other
Locations1 site (Istanbul)
StatusRecruiting
StartedAugust 2025
Main results expectedDecember 2025
Study endsJune 2026
Registry record updatedAugust 24, 2025
Trial IDNCT07104942 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65 with a confirmed diagnosis of non‑cystic fibrosis bronchiectasis who are not experiencing an acute infection at the time of assessment are ideal candidates.

Probably not a fit

People with cystic fibrosis, active respiratory infection, pregnancy, myopathies, recent stroke, or unstable cardiac disease are unlikely to benefit from or be eligible for this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure expiratory muscle strength in adults with non‑cystic fibrosis bronchiectasis and relate those measurements to clinical outcomes including disease severity, history of hospital admissions, cough effectiveness, and quality of life. Participants aged 18–65 without an acute infection will undergo respiratory muscle testing and clinical data collection. The study is conducted at a single chest diseases center in Istanbul and will use the findings to explore whether expiratory muscle weakness contributes to impaired airway clearance. Results are intended to inform future interventional research in pulmonary rehabilitation and respiratory muscle training.

Why it matters

Potential benefit: If expiratory muscle weakness is identified as a contributor to worse outcomes, targeted physiotherapy or respiratory muscle training could be developed to improve cough effectiveness, symptoms, and possibly reduce hospitalizations.

How similar studies have gone: Respiratory muscle training has shown benefits in other chronic lung diseases, but clear evidence specifically linking expiratory muscle strength to outcomes in bronchiectasis is limited and this application is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Having a diagnosis of non-cystic fibrosis bronchiectasis
* Without an acute infection at the time of assessment (confirmed by medical history, serum C-reactive protein levels, chest X-ray and/or HRCT).
* Being between 18 and 65 years of age

Exclusion Criteria:

* Myopathies
* Stroke (Cerebrovascular accident - CVA)
* Pregnancy
* Unstable cardiac disease

Where it's running

  • Süreyyapaşa Chest Diseases and Chest Surgery Training and Research Hospital
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.