Expiratory (breathing-out) muscle strength and health outcomes in bronchiectasis
Effect of Expiratory Muscle Strength on Hospital Admission, Disease Severity and Quality of Life in Patients With Bronchiectasis
This project tests whether weaker expiratory (breathing-out) muscles are linked to worse symptoms, more hospital visits, and lower quality of life in adults with non‑cystic fibrosis bronchiectasis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 64 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Saglik Bilimleri Universitesi Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07104942 on ClinicalTrials.gov |
What this trial studies
This observational study will measure expiratory muscle strength in adults with non‑cystic fibrosis bronchiectasis and relate those measurements to clinical outcomes including disease severity, history of hospital admissions, cough effectiveness, and quality of life. Participants aged 18–65 without an acute infection will undergo respiratory muscle testing and clinical data collection. The study is conducted at a single chest diseases center in Istanbul and will use the findings to explore whether expiratory muscle weakness contributes to impaired airway clearance. Results are intended to inform future interventional research in pulmonary rehabilitation and respiratory muscle training.
Who should consider this trial
Good fit: Adults aged 18–65 with a confirmed diagnosis of non‑cystic fibrosis bronchiectasis who are not experiencing an acute infection at the time of assessment are ideal candidates.
Not a fit: People with cystic fibrosis, active respiratory infection, pregnancy, myopathies, recent stroke, or unstable cardiac disease are unlikely to benefit from or be eligible for this study.
Why it matters
Potential benefit: If expiratory muscle weakness is identified as a contributor to worse outcomes, targeted physiotherapy or respiratory muscle training could be developed to improve cough effectiveness, symptoms, and possibly reduce hospitalizations.
How similar studies have performed: Respiratory muscle training has shown benefits in other chronic lung diseases, but clear evidence specifically linking expiratory muscle strength to outcomes in bronchiectasis is limited and this application is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having a diagnosis of non-cystic fibrosis bronchiectasis * Without an acute infection at the time of assessment (confirmed by medical history, serum C-reactive protein levels, chest X-ray and/or HRCT). * Being between 18 and 65 years of age Exclusion Criteria: * Myopathies * Stroke (Cerebrovascular accident - CVA) * Pregnancy * Unstable cardiac disease
Where this trial is running
Istanbul
- Süreyyapaşa Chest Diseases and Chest Surgery Training and Research Hospital — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Nisanur Tutuş
- Email: nisanurtutuss@gmail.com
- Phone: (0216) 421 42 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.