Exercise type and timing for blood pressure and eye pressure in glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ACHIEVE-project investigates the short-term safety and effects of aerobic, isometric, and moderate-to-high intensity exercise performed at different times of day on 24-hour ambulatory blood pressure and intraocular pressure in people with POAG and elevated BP. Participants will undergo supervised exercise sessions to measure post-exercise blood pressure changes and variability, aiming to identify the most beneficial and safe protocols. The study design focuses on feasibility, safety, and physiological responses rather than long-term outcomes. Results could inform non-drug strategies to manage blood pressure and eye pressure in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
* At least 18 years of age at the time of signing the Informed Consent Form (ICF)
* Patients with POAG AND \[elevated BP OR hypertension (Average SBP on Home BP ≥120 mmHg AND/OR Average DBP on Home BP ≥70 mmHg) with or without the use of anti-hypertensive medication\]
* Patients without recent changes in medication and glaucoma care within the past four weeks.

Exclusion Criteria:

* Not able to provide informed consent
* SBP and/or DBP are ≥ 150 mmHg and/or ≥ 95 mmHg, respectively, on office BP at screening AND on home BP measurement conducted in the week following screening (to identify White Coat Hypertension) to ensure safety. These patients require referral for early treatment.
* Aberrant cardiopulmonary exercise test (CPET) at screening (Life-threatening arrhythmias, ischemia,…)
* Unable to perform one or more of the four exercise sessions due to physical and or mental limitations (severe lung disease, musculoskeletal issues, unstable angina,…)
* Severe osteoarthritis pending knee replacement surgery (these patients may be unable to perform the IRE (i.e. wall squat exercise)
* Unable to communicate in Dutch
* Active malignancy
* Participation in an interventional Trial with an investigational medicinal product (IMP), exercise intervention or device
* Unwillingness to repeat ABPM
* Relative contraindications to ABPM: diagnosed atrial fibrillation, nighttime workers, occupational drivers

Where it's running

• UZ Leuven/KU Leuven
  Leuven, Belgium Recruiting

Study contacts

• Study coordinator: Véronique Cornelissen, MSc, PhD, Associate Professor
• Email: veronique.cornelissen@kuleuven.be
• Phone: +32 16 32 91 52

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.