Exercise to Reduce Hot Flushes in Postmenopausal Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial aims to compare the effects of strength training and high-intensity aerobic exercise on hot flushes in postmenopausal women. Participants will be assigned to one of three groups: strength training, high-intensity aerobic training, or an untreated control group. The study will assess the frequency and severity of vasomotor symptoms over 15 weeks, along with secondary outcomes such as quality of life and sleep quality. The goal is to identify effective, evidence-based exercise interventions for managing postmenopausal symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Postmenopausal women (one of: ≥ 12 months since last menstruation; amenorrhea due to intrauterine device or hysterectomy and Follicle Stimulating Hormone (FSH) \>30 mIU/ml; bilateral oophorectomy; induced menopause due to chemotherapy or radiation and ≥2 years amenorrhea);
* ≥ 28 moderate to severe hot flushes per week during a 2-week screening period, registered through a daily VMS diary;
* Age ≥45 years;
* Physical ability to participate in strength training or high intensity aerobic exercise for 60 minutes, 3 times/week during 15 weeks;
* Understand Swedish orally and in writing

Exclusion Criteria:

* Regular physical activity \>30 minutes per week of vigorous intensity or ≥150 minutes of moderate intensity or combined activities representing maximum 150 minutes of moderate intensity;
* Use of systemic menopausal hormone therapy the last 2 months;
* Use of natural preparations such as herbal preparations for VMS, or other medications for VMS the last 2 months;
* Capillary hemoglobin \<110 g/l;
* Blood pressure \>160 mmHg systolic or \>100 mmHg diastolic;
* Unstable medical condition with a potential to affect VMS (like unregulated thyroid disease);
* Medical condition that by a physician is judged not appropriate (because of potential to affect VMS or risk of injury with vigorous exercise)

Where it's running

• Region Kalmar Län
  Kalmar, Sweden Recruiting
• Region Östergötland
  Linköping, Sweden Recruiting

Study contacts

• Principal investigator: Anna-Clara Spetz Holm, Ass prof, MD — Region Östergötland, Linköping university
• Study coordinator: Anna-Clara Spetz Holm, Ass prof, MD
• Email: anna-clara.spetz.holm@liu.se
• Phone: +46101033130

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.