Exercise to improve outcomes in colorectal cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of aerobic and resistance exercise on patients with metastatic colorectal cancer undergoing palliative chemotherapy. It aims to determine whether exercise can reduce chemotherapy-related toxicity and prevent dose modifications, which are common in this patient population. The study will compare different types of exercise interventions to identify the optimal approach for enhancing physical fitness and quality of life during treatment. By exploring the relationship between exercise and cancer outcomes, the research seeks to provide evidence for integrating exercise into standard cancer care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* mCRC with indication for palliative chemotherapy
* scheduled for treatment with first-line doublet or triplet chemotherapy, according to the national guideline
* able and willing to give written informed consent.

Exclusion Criteria:

* life expectancy \<6 months
* unable to perform basic activities of daily living such as walking or biking
* presence of cognitive disorders or severe emotional instability (e.g., Schizophrenia, Alzheimer, alcohol addiction);
* presence of other disabling co-morbidities that might hamper physical exercise (e.g. heart failure (NYHA classes 3 and 4), chronic obstructive pulmonary disease (COPD, gold 3 and 4), orthopaedic conditions and neurological disorders (e.g., hernia, paresis, amputation, active rheumatoid arthritis);
* insufficient mastery of the Dutch language;
* presence of serious cardiovascular or cardiopulmonary conditions (e.g. unstable angina, arrhythmia or valve disease) such that exercise safety is at risk, as judged by the treating physician.
* Already participating in structured vigorous aerobic and/or resistance exercise ≥ 2 times per week comparable to our intervention

Where it's running

• Jeroen Bosch Ziekenhuis
  's-Hertogenbosch, Netherlands Recruiting
• Flevoziekenhuis
  Almere Stad, Netherlands Recruiting
• Meander Medisch Centrum
  Amersfoort, Netherlands Recruiting
• Ziekenhuis Amstelland
  Amstelveen, Netherlands Recruiting
• Amsterdam UMC
  Amsterdam, Netherlands Recruiting
• Netherlands Cancer Institute
  Amsterdam, Netherlands Recruiting

Study contacts

• Study coordinator: Laurien M Buffart, PhD
• Email: laurien.buffart@radboudumc.nl
• Phone: +31243613674

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Digital follow-up care for colorectal cancer survivors

  This study is testing a new digital follow-up care program for colorectal cancer survivors to see if it can better support their individual needs and improve their quality of life after treatment.

  Recruiting at 9 sites University of Aarhus · Herning, Central Jutland and 8 other locations · NCT06614647

• Observational study on young adult cancer survivors

  This study looks at young adults who have survived cancer to see how their long-term health and quality of life are affected.

  Recruiting The Netherlands Cancer Institute · Amsterdam, North Holland · NCT04682470

• Knife-assisted full-thickness resection for rectal lesions in a multicenter setting

  A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.

  Recruiting University Hospital, Ghent · Ghent · NCT07923682

• Personalized 3D Bioprinted Colorectal Cancer Microenvironment Model

  This study tests patient-derived, 3D-bioprinted cancer models that include tumor, fibroblast, and immune cells to see if they can better predict how colorectal cancer will respond to treatment.

  Recruiting Peking Union Medical College Hospital · Ningbo, Zhejiang · NCT07919418

• Integrated genomic and clinical database for cancer biomarker discovery

  Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.

  Recruiting Samsung Medical Center · Seoul, Gang-Nam · NCT07911267

• Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery

  Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.

  Recruiting Semmelweis University · Budapest · NCT07896174

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.