Exercise to improve blood vessel (endothelial) function in type 1 diabetes
Official title: Impact of Exercise Training on Endothelial Function in Adults With Type 1 Diabetes
Run by University Hospital, Lille · NCT03528226 · Data updated 2026-11-12
This trial will test whether a supervised exercise program can improve blood vessel function in adults with type 1 diabetes who do not yet have complications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 34 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Status | Recruiting |
| Started | November 12, 2019 |
| Main results expected | November 2028 |
| Study ends | November 2028 |
| Registry record updated | May 14, 2026 |
| Trial ID | NCT03528226 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with type 1 diabetes diagnosed at least one year, without microvascular or macrovascular diabetic complications, who are non-smokers, not obese (BMI <30 kg/m²), without hypertension or other active chronic diseases, and able to perform trunk and limb movements are the ideal candidates.
✕Probably not a fit
Patients who already have diabetic microvascular or macrovascular complications, who have obesity, smoke, have uncontrolled hypertension, other active chronic diseases, or who have non–type 1 forms of diabetes are unlikely to benefit from this preventive exercise program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized controlled trial comparing a structured exercise training program with usual life in adults with type 1 diabetes who are free of microvascular and macrovascular complications. Participants meeting strict inclusion and exclusion criteria will be assigned to supervised exercise sessions or to continue their normal activities. The primary outcome is change in endothelial function, and secondary outcomes include measures of micro- and macrovascular function, exercise-induced tissue vasoreactivity, and related neurometabolic changes. The approach is a non-pharmacological, preventive strategy aimed at improving early vascular health in this population.
Why it matters
Potential benefit: If successful, the exercise program could improve endothelial and overall vascular health and help delay or reduce early vascular complications in people with type 1 diabetes.
How similar studies have gone: Exercise interventions have improved endothelial function in other populations and small studies in type 1 diabetes suggest benefit, but larger randomized data in complication-free adults with type 1 diabetes remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Covered by social security * With a T1Diabete, diagnosed for at least 1 year, and free from macrovascular and microvascular diabetic complications. Exclusion Criteria: * type 1 diabetes diagnoses for less than 1 year * MODY diabetes, mitochondrial diabetes or type 2 diabetes * presence of macrovascular and/or microvascular diabetic complications (retinopathy, nephropathy, neuropathy ,…) * Obesity (Body Mass Index \> 30 kg/m² * Smokers * Hypertension * Disabling painful discomfort for trunk, upper or lower limb movements * Active chronic disease or in remission (excluding type 1 diabetes) * Head trauma in the past
Where it's running
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Hop Claude Huriez Chu Lille
Lille, France Recruiting
Study contacts
- Principal investigator: Anne Vambergue, MD,Phd — University Hospital, Lille
- Study coordinator: Anne Vambergue, MD,PhD
- Email: anne.vambergue@chu-lille.fr
- Phone: 320444184
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.