Exercise program to improve vision and health in Veterans with AMD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effects of a stationary bicycling exercise intervention on visual and overall health outcomes in Veterans diagnosed with intermediate Age Related Macular Degeneration (AMD). Participants will be compared to a control group engaging in non-aerobic exercises, with assessments conducted before, during, and after a 6-month intervention period. The study will measure visual acuity, cognitive function, and physical performance to determine the potential benefits of aerobic exercise in preserving vision and enhancing quality of life for older Veterans. The findings may pave the way for larger trials to further explore the impact of exercise on AMD progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The investigators will recruit Veterans with a diagnosis of intermediate stage AMD in at least one eye, aged 65-89, willing and able to cooperate with assessments and interventions.
* Eligible participants will be quantified \> 26 on the Montreal Cognitive Assessment (MoCA) to meet the criteria for cognitively intact.
* Participants will be free from diseases affecting cognition or ability to engage in aerobic exercise (including but not limited to chronic heart, liver, or kidney disease) and from diseases/injuries directly affecting brain functions (including but not limited to significant closed head injury, open intracranial wounds, stroke, epilepsy, degenerative diseases of the nervous system).
* Eligible participants will be required to have stable internet access in their home.
* All subjects will speak English as a primary language and will have graduated high school so that behavioral/cognitive measures reflect effects of age, AMD, and/or aerobic exercise and not the effects of familiarity with English or lack of education.

Exclusion Criteria:

* Other, non-AMD, visual impairments. Potential participants with major psychiatric disorder (including but not limited to psychosis, major depression, bipolar disorder) by history will be excluded as well as individuals with current alcohol or substance use disorder.
* Additionally, individuals with cardiovascular disease and or history of myocardial infarction will not be included.

Where it's running

• Atlanta VA Medical and Rehab Center, Decatur, GA
  Decatur, Georgia, United States Recruiting

Study contacts

• Principal investigator: Joe R. Nocera, PhD — Atlanta VA Medical and Rehab Center, Decatur, GA
• Study coordinator: Joe R Nocera, PhD
• Email: joenocera@emory.edu
• Phone: (404) 321-6111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.