Clinical trial No longer in our active list Interventional Ages 6 to 17

Exercise program for children with sickle cell disease

Official title: Sickle Cell Children's Exercise Study Determining the Effects of a Targeted Exercise Training Program on Neuromuscular Performance, Locomotor Efficiency, and Exercise Tolerance in Children with Sickle Cell Disease.

Run by University of Maryland, Baltimore · NCT06074198 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study tests whether a six-week exercise program can help children with sickle cell disease improve their strength, balance, speed, and agility.

Quick facts

Study typeInterventional
Ages6 Years to 17 Years
SexAll
Enrollment20 (estimated)
SponsorUniversity of Maryland, Baltimore
Academic / other
Locations2 sites (Baltimore, Maryland and 1 other locations)
Trial IDNCT06074198 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are children aged 6-17 years who have been diagnosed with sickle cell disease.

Probably not a fit

Patients with neurological disorders unrelated to sickle cell disease or those with recent lower extremity injuries may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Sickle Cell Children's Exercise Study (SuCCESs) aims to evaluate the feasibility and effects of a moderate intensity exercise program focusing on strengthening, balance, speed, and agility in children diagnosed with sickle cell disease. Participants will undergo a baseline assessment followed by six weeks of the SuCCESs program, which includes attending six in-person physical therapy sessions and completing additional home exercises. After the intervention, a post-assessment will be conducted to measure the outcomes of the program.

Why it matters

Potential benefit: If successful, this program could improve physical performance and overall quality of life for children with sickle cell disease.

How similar studies have gone: While there is limited data on similar exercise interventions specifically for sickle cell disease, other studies have shown positive outcomes in physical therapy for chronic conditions in children.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Children 6-17 years of age diagnosed with sickle cell disease

Exclusion Criteria:

* Diagnosis of neurological disorder, not related to sickle cell disease
* Lower extremity injury such as a fracture with a cast

Where it's running

  • University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science
    Baltimore, Maryland, United States
    Recruiting
  • University of Maryland, Baltimore
    Baltimore, Maryland, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Cerebrovascular Reactivity Testing with HD-DOT in Sickle Cell Patients

    This study tests whether high-density diffuse optical tomography can measure brain blood flow and oxygen use in people with sickle cell disease, to see how these signals relate to stroke risk.

    Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07776444

  • Adapting and testing PEN-Plus in Zambian primary care

    Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

    Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

  • Newborn Sickle Cell Screening in Mozambique

    We’re testing a three-part plan to help babies in Mozambique get diagnosed early for sickle cell disease and start care quickly.

    Recruiting St. Jude Children's Research Hospital · Nhamatanda, Sofala · NCT07719972

  • Optimizing Hydroxyurea in Children with Sickle Cell in Africa

    This study tests whether raising hydroxyurea to a maximum tolerated dose is safe and beneficial for Ugandan children with sickle cell anemia already taking a fixed daily dose.

    Recruiting Phase 1/2 Children's Hospital Medical Center, Cincinnati · Kampala · NCT07708714

  • Hematopoietic stem cell editing to treat sickle cell disease

    This study tests whether a patient’s own blood stem cells can be edited to remove the sickle cell triggering gene and then returned to the patient.

    Recruiting Phase 1 Boston Children's Hospital · Boston, Massachusetts · NCT07708350

  • Virtual reality options to help with VOC pain in adults with SCD

    This study tests whether headset-based virtual reality can help reduce pain for adults with sickle cell disease during vaso-occlusive crises treated in an infusion center.

    Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT07674277

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.