Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Exercise program for adults with mild to moderate cognitive impairments

Official title: Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

Run by University of South Carolina · NCT06799429 · Data updated 2026-11-12

This study tests a 6-month exercise program for adults with mild to moderate cognitive impairments to see if it helps them feel better and improve their physical and mental abilities.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorUniversity of South Carolina
Academic / other
Locations2 sites (Columbia, South Carolina and 1 other locations)
StatusRecruiting
StartedMarch 13, 2026
Main results expectedOctober 31, 2026
Study endsNovember 17, 2026
Registry record updatedJune 1, 2026
Trial IDNCT06799429 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults diagnosed with mild to moderate cognitive impairment who are medically cleared for exercise.

Probably not a fit

Patients with significant pain during movement or severe balance impairments may not benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates a 6-month exercise program designed for adults with mild to moderate cognitive impairments in South Carolina. Participants will engage in moderate intensity exercise twice a week, either in-person with a coach or through a distance program with coaching support. The study aims to assess the practicality and enjoyment of the program, as well as its effects on endurance, mobility, and cognitive function over time. Participants will receive individualized exercise plans based on their initial assessments and will be monitored for progress.

Why it matters

Potential benefit: If successful, this program could improve physical fitness and cognitive function in individuals with cognitive impairments.

How similar studies have gone: Other studies have shown positive outcomes with exercise interventions for cognitive impairments, suggesting this approach is promising.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* adult (age \>18)
* medical diagnosis of mild-moderate cognitive impairment
* medical clearance by referring provider for exercise
* able to follow 2-step commands

Exclusion criteria:

* significant pain with movement (\>5/10)
* severe balance impairments or lack of independence on and off exercise equipment (by physical therapist judgment at Intake)

Where it's running

  • Arnold School of Public Health
    Columbia, South Carolina, United States
    Recruiting
  • Sumter YMCA
    Sumter, South Carolina, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.