Mindful walking and its effect on executive function in older adults at risk for dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 2 randomized pilot trial compares mindful walking to walking alone in adults aged 60 and older who are sedentary and have at least one risk factor for dementia. Brain activity will be measured with functional near-infrared spectroscopy (fNIRS) to explore neural changes associated with executive function. The study aims to determine feasibility, safety, and potential cognitive benefits to inform a future larger trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 60 or older
2. Sedentary (sit ≥9hrs per day) and not meeting the US physical activity guidelines
3. Have at least one of the following ADRD risk factors:

   i. family history of ADRD (\>= first-degree relative) ii. subjective experience of cognitive complaints iii. currently overweight or obese (BMI≥25)
4. Adequate hearing, visual and cognitive ability to complete study tasks and assessments
5. Able to walk without others' assistance
6. Medically stable with or without medication (do not expect to have major health status changes or a surgery in the next 4 months)

Exclusion Criteria:

1. Diagnosis of ADRD or other brain abnormalities (i.e., strokes, epilepsy, Parkinson's disease)
2. Diagnosis of mental disorders (i.e., depression)
3. Inability to complete surveys on mobile device or wear the activity monitor (i.e., due to arthritis, physical limitations, or other reasons)
4. Plan to move or have surgery in next 4 months
5. Currently participate in other study involving physical activity or cognitive training that may interfere with the study outcomes
6. Unable to provide consent due to disabilities

Where it's running

• University of South Carolina
  Columbia, South Carolina, United States Recruiting

Study contacts

• Study coordinator: Halle Prine, MS
• Email: HPRINE@email.sc.edu
• Phone: 8039997392

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.