Exercise improves gut health in patients on peritoneal dialysis

Exercise Improves Gastrointestinal Function in Peritoneal Dialysis Patients: A Single Center Prospective Randomized Controlled Study

This study is testing if regular exercise can improve gut health in people on peritoneal dialysis to help them feel better overall.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 132 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Sichuan Academy of Medical Sciences (Academic / other)
• Locations: 1 site (Chengdu, Sichuan)
• Trial ID: NCT06368713 on ClinicalTrials.gov

What this trial studies

This study investigates how exercise affects gastrointestinal function in patients undergoing peritoneal dialysis. It recognizes that gastrointestinal health is crucial for these patients, as disturbances can impact dialysis effectiveness and quality of life. Participants will be randomly assigned to either an exercise group or a control group, with data collected over four months to evaluate the benefits of physical activity on their gastrointestinal health. The study aims to fill a gap in understanding the specific effects of exercise on this patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 65 who have been on peritoneal dialysis for more than three months and are proficient in smartphone use.

Not a fit: Patients with severe cardiovascular diseases or unstable blood pressure may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance gastrointestinal function and overall quality of life for patients on peritoneal dialysis.

How similar studies have performed: While the role of exercise in chronic conditions is recognized, the specific impact on gastrointestinal function in peritoneal dialysis patients has not been extensively studied, making this approach novel.

Eligibility criteria

Inclusion Criteria:

1. Patients must have undergone peritoneal dialysis for more than 3 months.
2. Age between 18 and 65 years.
3. Possession of a smartphone and proficiency in its usage.
4. Willingness to provide voluntary informed consent by signing the consent form.

Exclusion Criteria:

1. Recent systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg, or systolic blood pressure ≤90 mmHg or diastolic blood pressure ≤60 mmHg within the past week.
2. Presence of severe cardiovascular diseases, including but not limited to:

   * Heart failure classified as New York Heart Association (NYHA) functional grade IV-V.
   * Severe arrhythmias such as third-degree atrioventricular block, sick sinus syndrome, paroxysmal supraventricular tachycardia, or ventricular tachycardia.
   * Unstable angina.
   * Pulmonary arterial hypertension with pulmonary arterial pressure ≥25 mmHg.
   * Severe pericardial effusion, valve stenosis, hypertrophic cardiomyopathy, or aortic dissection.
3. Severe pulmonary diseases, including but not limited to:

   * Severe chronic obstructive pulmonary disease (COPD).
   * Pulmonary embolism.
   * Lung cancer.
   * Severe pulmonary infection.
4. Presence of deep venous thrombosis.
5. Severe neurological, muscular, bone, or joint diseases that hinder compliance with exercise.
6. Participation in other concurrent exercise programs.

Where this trial is running

Chengdu, Sichuan

• Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital,School of Medicine, University of Electronic Science and Technology of China — Chengdu, Sichuan, China (Recruiting)

Study contacts

• Principal investigator: Jin Chen, Doctor — Sichuan Academy of Medical Sciences , University of Electronic Science and Technology of China,
• Study coordinator: Jin Chen, Doctor

Conditions Peritoneal Dialysis; Exercise; Gastrointestinal Function; Quality of Life; Chronic Kidney Diseases; Exercise intervention; Gastrointestinal function; Telehealth