Exercise and nutrition interventions for chemotherapy-induced neuropathy
Official title: The Effects of Exercise and Nutrition Interventions on Chemotherapy-induced Peripheral Neuropathy and Interoceptive Brain Circuitry
Run by University of Rochester · NCT03858153 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if exercise and nutrition education can help women with breast cancer who are experiencing nerve pain from chemotherapy feel better.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 80 (estimated) |
| Sponsor | University of Rochester Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Baltimore, Maryland and 1 other locations) |
| Trial ID | NCT03858153 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are sedentary women diagnosed with breast cancer who are scheduled to receive taxane chemotherapy.
✕Probably not a fit
Patients who are already active in exercise or have physical limitations that prevent participation in the study will not benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase II randomized controlled trial investigates the effects of exercise and nutrition education on chemotherapy-induced peripheral neuropathy (CIPN) in women undergoing taxane chemotherapy for breast cancer. The study aims to evaluate the preliminary efficacy of these interventions while exploring the roles of inflammation and interoception. Participants will be randomly assigned to either an exercise program or nutrition education to assess their impact on CIPN symptoms. The trial seeks to gather data that will inform future studies with a more accurate effect size.
Why it matters
Potential benefit: If successful, this study could provide effective non-pharmacological interventions to alleviate CIPN symptoms in breast cancer patients undergoing chemotherapy.
How similar studies have gone: Other studies have shown promise in using exercise and nutrition interventions for managing chemotherapy side effects, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria (subjects must...) 1. Be female 2. Have breast cancer 3. Be scheduled to receive taxane chemotherapy without other neurotoxic chemotherapy (platinums, vinca alkaloids, bortezomib, thalidomide) 4. Have at least six months life expectancy according to the patient's oncologist or designee 5. Be able to read English 6. Be at least 18 years old (no upper limit on age) 7. Provide written informed consent Exclusion criteria (subjects must not...) 1. Be in the active or maintenance stage of exercise behavior (i.e., subjects must be sedentary) 2. Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in maximal physiological fitness testing and a low/moderate intensity home-based walking and progressive resistance exercise program. Additional exclusion criteria only for patients performing the MRI scanning (40 of 80 enrolled subjects) 1. Subjects must not have contraindications for MRI scanning (pacemaker, metal implants, pregnancy, chest expander from breast reconstruction, etc.-note that most port-a-caths are safe for MRI scanning)
Where it's running
-
University of Maryland
Baltimore, Maryland, United States Recruiting -
University of Rochester Medical Center
Rochester, New York, United States Active not recruiting
Study contacts
- Study coordinator: Ian Kleckner, PhD, MPH
- Email: ian.kleckner@umaryland.edu
- Phone: 410-706-5981
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.