Exercise and cognitive rehabilitation for older cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older cancer survivors who report memory or thinking problems after treatment will be assigned to one of three active interventions—an integrated exercise plus cognitive rehab program (ECO), an exercise program adapted for home and digital tracking (EXCAP), or a cognitive rehabilitation program (MAAT)—or to usual care. Interventions are delivered with home-based components and digital support for exercise adherence, while cognitive training is delivered according to the MAAT protocol. The primary outcome is objective cognition as measured by the Trail Making Test, with other clinical and adherence measures collected. Eligible participants are adults aged 65 or older who have completed curative-intent cancer treatment and can safely perform low-to-moderate exercise.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age ≥65 years (from date of consent, confirmed on the electronic medical record)
* A diagnosis of any cancer
* Have completed curative intent treatments

  * Patients on endocrine therapies are allowed to enroll
  * Patients with hematologic malignancies after autologous or allogeneic stem cell transplant are allowed to enroll if they have completed curative-intent treatment
* Answered "yes" to the verbal question "Do you have concerns about memory or other thinking abilities following your cancer treatment?"
* Able to speak English (interventions are available in English only)
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-3#
* No medical contraindications to exercise#
* Able to walk 4 meters#
* Able to provide informed consent#

  * Confirmed through eligibility confirmation with the patient's oncologist or their designee

Exclusion criteria:

* Any physical, psychological, or social impairments that would interfere with a patient's ability to participate in the study as determined by the patient's oncologist or their designee
* Unwilling to complete study procedures

Where it's running

• University of Rochester
  Rochester, New York, United States Recruiting

Study contacts

• Principal investigator: Kah Poh Loh — University of Rochester
• Study coordinator: Kah Poh Loh
• Email: Kahpoh_Loh@URMC.Rochester.edu
• Phone: 585-276-4353

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gyrotonic exercise for elders with breast cancer and Behcet disease

  We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.

  Recruiting Cairo University · Giza, Dokki · NCT07929116

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• CG-7321: a first-in-human test in advanced solid tumors

  We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.

  Recruiting at 4 sites Phase 1 Chengdu Cynogen Bio-pharmaceutical Tech. Co., Ltd. · Fuzhou, Fujian and 3 other locations · NCT07923214

• Compare a new endoscopy-assisted breast-conserving surgery with the usual approach

  This study tests whether a new endoscopy-assisted breast-conserving technique can provide similar or better cosmetic outcomes and safety compared with conventional breast-conserving surgery in women with early breast cancer who want to preserve their breast.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang and 21 other locations · NCT07920094

• Different skin care approaches to prevent skin reactions after mastectomy radiation

  This study tests three standard skin care methods to see which best prevents radiation dermatitis in people who had a mastectomy and are receiving post-mastectomy radiation therapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07918989

• 3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy

  This study tests whether 3D echocardiography can detect early heart damage from cancer treatments like anthracyclines or HER2-targeted therapy better than standard 2D methods.

  Recruiting Region Skane · Lund, Skåne County · NCT07916337

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.