Examining the role of endothelial glycocalyx in kidney transplantation
The Role of Endothelial Glycocalyx in Kidney Transplantation
This study looks at how a special layer on blood vessels affects kidney transplants by checking its condition in both donors and recipients to see if it can help improve transplant success.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Sex | All |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 1 site (Hradec Králové, Czech Republic) |
| Trial ID | NCT05651906 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the endothelial glycocalyx (EG) and its significance in kidney transplantation. Researchers will assess markers of EG degradation in blood and urine, and utilize sidestream dark field imaging (SDF) for direct visualization of EG in both kidney donors and recipients. The study aims to enhance understanding of EG's role in microcirculation and tissue metabolism, and its implications for graft function and survival. By summarizing current knowledge, the research seeks to highlight the importance of EG in the context of kidney transplantation.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing kidney transplantation.
Not a fit: Patients who do not sign the informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved graft function and survival in kidney transplant patients.
How similar studies have performed: While the role of endothelial glycocalyx in various conditions has been explored, this specific focus on kidney transplantation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing kidney transplantation Exclusion Criteria: * Patients who don't sign the informed consent
Where this trial is running
Hradec Králové, Czech Republic
- University Hospital Hradec Kralove — Hradec Králové, Czech Republic, Czechia (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.