Examining the relationship between rheumatoid arthritis and osteosarcopenia
The Frequency of Osteosarcopenia in Patients With Rheumatoid Arthritis and the Factors Affecting the Sarcopenia-osteoporosis Relationship
This study is trying to see how common muscle and bone problems are in people with rheumatoid arthritis compared to healthy individuals to understand how these issues affect their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Konya Beyhekim Training and Research Hospital Government |
| Locations | 1 site (Konya, Selçuklu) |
| Trial ID | NCT06889415 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the prevalence of sarcopenia and osteoporosis in patients with rheumatoid arthritis (RA) against a matched control group of healthy individuals. It will include 100 RA patients and 100 healthy controls, focusing on the impact of sarcopenia on osteoporosis, fall risk, and fracture risk. Participants will undergo detailed medical history assessments, clinical examinations, and various tests to evaluate their health status and disease activity levels. The study seeks to provide insights into the interconnectedness of these conditions in RA patients.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with rheumatoid arthritis aged 50 and older.
Not a fit: Patients with acute illnesses, significant cognitive impairments, or other serious health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how sarcopenia affects osteoporosis in RA patients, potentially leading to improved management strategies.
How similar studies have performed: While the relationship between RA and osteosarcopenia has been explored, this specific comparative approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Being diagnosed with RA according to the ACR/EULAR 2010 criteria 2. Being a female or male over the age of 50 3. Having the mental and physical capacity to complete the study questionnaires and tests 4. Providing voluntary consent to participate in the study by signing the Informed Consent Form Exclusion Criteria: 1. Having an acute illness/disability or significant cognitive impairment that prevents understanding and performing the required tests 2. Having thyroid or parathyroid disease, uncontrolled diabetes, Cushing's syndrome, anemia. 3. History of malignancy 4. Severe cardiovascular disease, enal failure, advanced-stage COPD, decompensated liver disease 5. History of gastrointestinal (GIS) surgery 7-Having another coexisting autoimmune/inflammatory rheumatic disease (e.g., SLE, Ankylosing Spondylitis, etc.), psoriatic arthritis, vasculitis, familial Mediterranean fever...) 8-Having severe/symptomatic hand osteoarthritis and/or deformities 9-Severe/symptomatic osteoarthritis in the knee, lumbar, hip, or ankle region 10-Having Carpal Tunnel Syndrome, De Quervain, lateral epicondylitis, cubital tunnel syndrome or a history of traumatic hand injury 11-Having a significant neurological disease, stroke, MS, myopathy, Parkinson's disease, radiculopathy/polyneuropathy/brachial plexopathy or others nerve root compressions 12-History of surgical intervention on the upper and lower extremities or spine 13-Having severe kyphosis or scoliosis 14-Having any others disease causing balance disorders (neurological, orthopedic, metabolic, etc.) 15-Having a major/significant psychiatric disorder (based on the medical history, and hospital records) 16-Current use of androgens or estrogens 17-Having prostheses, being fully dependent, or immobilized
Where this trial is running
Konya, Selçuklu
- Konya Beyhekim Training and Research Hospital Physical Medicine and Rehabilitation Clinic — Konya, Selçuklu, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: İlhan ç KAYA — Konya Beyhekim Training and Research Hospital Physical Medicine and Rehabilitation Clinic
- Study coordinator: ilhan ç KAYA
- Email: icaglar.kaya@gmail.com
- Phone: 09005377889686
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.