Examining the microbiological diversity in exhaled air of COPD and non-COPD patients
Study of Microbiological Diversity in Exhaled Air in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Subjects Free of COPD
This study is trying to see how the germs in the breath of people with COPD compare to those without the condition to better understand their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 240 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Intercommunal Creteil Academic / other |
| Locations | 1 site (Créteil) |
| Trial ID | NCT05437198 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the microbiological diversity present in the exhaled air of patients with chronic obstructive pulmonary disease (COPD) and those without the condition. Participants will be recruited during medical visits in the Departments of Pneumology and Occupational and Environmental Pathologies, where their clinical data, health status, and smoking history will be collected. Exhalation samples will be taken from different groups based on their health status, age, and smoking habits, with a follow-up collection scheduled for one year later.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with a diagnosis of COPD or healthy individuals aged 18-30 and 45-70 without COPD.
Not a fit: Patients with chronic infectious pulmonary conditions or those on specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the microbiome's role in COPD, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: While studies on microbiological diversity in respiratory conditions exist, this specific approach focusing on exhaled air in both COPD and non-COPD patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For COPD: * Patients with chronic obstructive pulmonary disease * Age: over 18 For non-COPD * Absence of chronic obstructive pulmonary disease * Age: between 18 and 30 years old and between 45 and 70 years old Exclusion Criteria: * Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants) * Person under guardianship or curatorship * Pregnant or breastfeeding women * Person unable to express his/her opposition, person deprived of liberty * Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
Where this trial is running
Créteil
- Centre Hospitalier Intercommunal de Créteil — Créteil, France (Recruiting)
Study contacts
- Principal investigator: Jean Claude PAIRON, PhD — CHI créteil
- Study coordinator: Jean-Claude PAIRON, PhD
- Email: jc.pairon@chicreteil.fr
- Phone: 01 45 02 20 93
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.