Examining the link between gut bacteria and immune response in infants with bronchiolitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between dysbiosis, or microbial imbalance, and immune responses in infants under 12 months suffering from bronchiolitis, primarily caused by respiratory syncytial virus (RSV). The study will enroll 80 infants, both hospitalized and non-hospitalized, during the RSV epidemic season. Researchers will collect oral, nasal, and stool samples to analyze the microbiota and a capillary blood sample for immune response evaluation. The goal is to better understand how these factors influence the severity and progression of bronchiolitis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants \<12 months
* With bronchiolitis during RSV epidemic season
* No chronic illness
* No bronchiolitis medical history
* Signed consent from parents or legal guardians

Exclusion Criteria:

* Chronic respiratory illness
* Medical history of bronchiolitis or newborn asthma
* Treatment with immunosuppressants
* Patient with no social security affiliation

Where it's running

• APHP, Antoine Béclère Hospital
  Clamart, France Recruiting
• AP-HP,Raymond Poincaré Hospital
  Garches, France Recruiting
• Réanimation médico-chirurgicale Necker
  Paris, France Recruiting

Study contacts

• Principal investigator: Etienne BIZOT, Doctor — AP-HP Hôpital Antoine Beclere
• Study coordinator: Etienne BIZOT, Doctor
• Email: etienne.bizot@aphp.fr
• Phone: 33145374618

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.