Examining the impact of preoperative anemia on surgical complications

Impact of Preoperative Anemia Severity and Classification on Perioperative Oxygen Supply-Demand Imbalance-Related Complications--A Prospective Observational Multi-center Cohort Study

This study is trying to see how different types of anemia before surgery affect the risk of complications during and after moderate- to high-risk surgeries.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Peking Union Medical College Hospital (Academic / other)
• Locations: 11 sites (Wuhu, Anhui and 10 other locations)
• Trial ID: NCT06499974 on ClinicalTrials.gov

What this trial studies

This observational study investigates how different types of preoperative anemia affect the incidence of perioperative complications in patients undergoing moderate- to high-risk surgeries. It classifies anemia into categories such as iron-deficiency anemia, anemia of chronic disease, and combined anemia, and compares these groups to a control group of patients without anemia. The study involves screening patients based on specific inclusion and exclusion criteria, measuring hemoglobin levels, and conducting lab tests to assess anemia status. All participants will undergo similar perioperative assessments and follow-ups to evaluate outcomes related to oxygen supply and demand imbalances.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older scheduled for elective moderate- to high-risk surgeries lasting over one hour.

Not a fit: Patients with severe comorbidities, hematological diseases other than anemia, or those living at high altitudes may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the management of anemia in surgical patients, potentially reducing complications and enhancing recovery.

How similar studies have performed: Previous studies have indicated that managing anemia preoperatively can lead to better surgical outcomes, suggesting this approach has potential based on existing evidence.

Eligibility criteria

Inclusion Criteria:

* age 18 years or older
* scheduled for elective moderate- to high-risk surgery other than intracranial and cardiac surgery
* predicted surgery time longer than 1 hour and hospital stay longer than 24 hours
* understand and agree to participate

Exclusion Criteria:

* pregnant
* live at areas higher than 2,500 meters above sea level
* with hematological diseases other than anemia
* with severe comorbidities that might interfere outcome assessment, like uremia, dementia, and so on
* can't cooperate or communicate, or reject to sign informed consent form

Where this trial is running

Wuhu, Anhui and 10 other locations

• Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College — Wuhu, Anhui, China (Recruiting)
• Beijing Longfu Hospital (Beijing Geriatric Hospital of Integrated Traditional Chinese and Western Medicine) — Beijing, Beijing Municipality, China (Recruiting)
• Anesthesiology Department, Beijing NO.6 Hospital — Beijing, Beijing Municipality, China (Recruiting)
• BeiJing Hepingli Hospital — Beijing, Beijing Municipality, China (Recruiting)
• Beijing Puren Hospital — Beijing, Beijing Municipality, China (Recruiting)
• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)
• Science and Education Department, Zhangzhou Municipal Hospital of Fujian Province — Zhangzhou, Fujian, China (Recruiting)
• Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University — Zunyi, Guizhou, China (Recruiting)
• Department of Anesthesiology, Chifeng Municipal Hospital — Chifeng, Inner Mongolia, China (Recruiting)
• Department of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University — Hohhot, Inner Mongolia, China (Recruiting)
• Inner Mongolia People's Hospital — Hohhot, Inner Mongolia, China (Recruiting)

Study contacts

• Study coordinator: Lu Che

Conditions Anemia