Examining the effects of passive leg movement on blood flow in stroke survivors
Passive Limb Movement Study
This study is testing how moving the legs without effort can improve blood flow in stroke survivors and if it works better with certain techniques compared to healthy individuals.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 55 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT05935670 on ClinicalTrials.gov |
What this trial studies
This study investigates how passive leg movement affects femoral blood flow in stroke survivors, who often experience compromised vascular function. It aims to assess the blood flow response to both passive movements and active leg contractions, which may be linked to neuromuscular function. The study will also explore whether ischemic conditioning can enhance these blood flow responses. Participants will include stroke survivors, age- and sex-matched controls, and young healthy adults.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18-85 who are post-stroke with residual hemiparesis.
Not a fit: Patients who are unable to stand or walk without assistance or have contraindications to ischemic conditioning may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved vascular function and exercise tolerance in stroke survivors.
How similar studies have performed: Preliminary data suggest that ischemic conditioning may improve vascular function in healthy adults and stroke survivors, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals Post-Stroke * 18 - 85 years of age * Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis * Able to give informed consent and follow 2-step command. * English Speaking * Age- and Sex-Matched Controls (CON) * Matched to age of individual post- stroke ± 5 years. * Matched to sex of individual post-stroke * Able to give informed consent and follow 2-step command. * English Speaking * Young Healthy Adults (CONyoung) * Age 18-30 years old * Able to give informed consent and follow 2-step command. * English Speaking Exclusion Criteria: * All Groups * Unable to stand from chair and walk 10 meters without physical assistance from another person (able to use assistive device). * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg). * Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization) * Low back or hip pain that limits lower extremity motor testing. * History of head trauma or concussion within the past 6 months * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg * Pregnancy or breastfeeding. * Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator * CON and CONyoung * History of Stroke
Where this trial is running
Milwaukee, Wisconsin
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Matthew Durand, PhD — Medical College of Wisconsin
- Study coordinator: Jennifer Nguyen
- Email: jnguyen@mcw.edu
- Phone: 414-955-5619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.