Examining the effects of micro and nanoplastics in patients with chronic kidney disease
Biomonitoring of Internal Exposure to MNPLs (Micro and NanoPlastics), and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)
This study is trying to see if tiny plastic particles in the blood of people with chronic kidney disease affect their health and immune system, especially those on hemodialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Universitat Autonoma de Barcelona Academic / other |
| Locations | 1 site (Murcia) |
| Trial ID | NCT05155267 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the presence and effects of micro and nanoplastics (MNPLs) in the blood of patients with chronic kidney disease (CKD), particularly those undergoing hemodialysis. It aims to detect MNPLs in biological fluids and assess potential genotoxic and immunological damage associated with exposure. The study will analyze biomarkers of exposure and genetic damage, as well as the impact on microbiota, using samples from urine, blood, and feces. The findings could enhance understanding of the health risks posed by MNPLs in vulnerable populations.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 85 with chronic kidney disease, either on hemodialysis for over three months or pre-dialysis with specific health criteria.
Not a fit: Patients without chronic kidney disease or those with active neoplasia or infectious diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the health impacts of micro and nanoplastics on patients with chronic kidney disease.
How similar studies have performed: While the effects of microplastics on health are being explored, this specific approach focusing on CKD patients is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for Chronic Kidney Disease (CKD) submitted to Hemodialysis: * Participant submitted to hemodialysis for more than 3 months * Between 18 and 85 years old * Stable haemoglobin (more than 10 gr/dl) * Absence of infectious disease at the date of sample collection and for a period of more than two weeks * Absence of active neoplasia * Stable vascular access Inclusion Criteria for Chronic Kidney Disease (CKD) pre-dialysis: * No hemodialysis treatment * Between 18 and 85 years old * Stable haemoglobin (more than 10 gr/dl) * Glomerular filtration ≤ 20 ml/min * Absence of infectious disease at the date of sample collection and for a period of more than two weeks * Absence of active neoplasia Inclusion Criteria for controls : * Between 18 and 85 years old (paired by gender, age and lifestyle to the CKD patients) * Absence of chronic kidney disease or dialysis treatment * Absence of chronic pathology (including neoplasia) * Absence of infectious disease at the date of sample collection and for a period of more than two weeks * Spanish residence Exclusion Criteria for both groups of CKD patients: * Clinical instability * Life expectancy of less than 12 months * Coagulation system disorders * Participation in other clinical study * Pregnancy * Unsigned informed consent Exclusion criteria for controls: * Participation in other clinical study * Pregnancy * Unsigned informed consent
Where this trial is running
Murcia
- Servicio Murciano de Salud — Murcia, Spain (Recruiting)
Study contacts
- Principal investigator: Pablo Pelegrín — Instituto Murciano de Investigación Biosanitaria (IMIB)
- Study coordinator: Ricard Marcos
- Email: ricard.marcos@uab.cat
- Phone: +34 93 586 20 52
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.