Examining the effects of a Mediterranean diet on Parkinson's Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to assess the feasibility and effects of an 18-month Mediterranean-style diet intervention compared to a standard diet in individuals living with Parkinson's Disease who do not have dementia. Participants will be randomly assigned to either diet group and will receive virtual nutrition coaching and cooking classes, along with regular in-person assessments at the University of British Columbia. The study will monitor changes in gut microbiome and Parkinson's symptoms, utilizing wearable devices to track physical activity and lifestyle factors throughout the intervention period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Eligible if the person living with Parkinson's has/is:

1. a clinical diagnosis of PD,
2. cognitively stable (no clinical dementia),
3. between 40-80 years old,
4. able to travel to UBC for 6 onsite visits over 18 months,
5. sufficient English proficiency (coaching and cooking classes are in English only),
6. on a stable dopaminergic medication for at least one month before baseline,
7. computer and internet access at home, and can be available via video link for at least 80% of the study sessions.

Exclusion Criteria:

Not eligible, if person has/is:

1. a diagnosis of atypical parkinsonism,
2. medical or psychiatric conditions that would prevent full participation in the nutrition intervention (such as food allergies), significant dysphagia, diabetes on insulin, anti-coagulation on warfarin, and inflammatory bowel disease,
3. clinical dementia,
4. unable to complete questionnaires or understand study instructions,
5. using of immunomodulatory agents,
6. used Probiotics in the last 4 weeks prior to study start,
7. used Antibiotics in the last 3 months prior to study start,
8. contraindications for MRI.

Where it's running

• UBC Pacific Parkinson's Research Centre
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Silke Appel-Cresswell, MD, FRCPC — University of British Columbia
• Study coordinator: Annie Kuan
• Email: annie.kuan@ubc.ca
• Phone: 604-827-0576

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.