Examining symptoms and severity of mitral regurgitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with mitral regurgitation who are undergoing left heart catheterization prior to mitral valve surgery or intervention. Participants will undergo a series of evaluations including cardiovascular magnetic resonance imaging (CMR), cardiopulmonary exercise testing (CPET), and the Kansas City Cardiomyopathy Questionnaire (KCCQ) to assess their symptoms, exercise capacity, and the severity of their condition. The study aims to explore the relationship between diastolic dysfunction and symptoms in patients with mitral regurgitation, providing insights into how these factors interact. By measuring intracardiac pressures and volumes during catheterization, researchers hope to better understand the underlying mechanisms of symptoms in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>=18 years of age
* Able to give informed consent
* Primary (degenerative) mitral regurgitation
* LVEF \>=50%
* Undergoing cardiac catheterization
* Able to exercise on a treadmill

Exclusion Criteria:

* Unable to give informed consent
* Secondary (functional) mitral regurgitation
* LVEF \<50%
* Known coronary artery stenosis \>=70% or past revascularization
* More than mild aortic stenosis, mitral stenosis, aortic regurgitation, tricuspid regurgitation, or pulmonic regurgitation
* Hypertrophic cardiomyopathy
* Pregnancy

Where it's running

• Morristown Medical Center
  Morristown, New Jersey, United States Recruiting

Study contacts

• Study coordinator: Medical Director, Cardiovascular Imaging, MD
• Email: seth.uretsky@atlantichealth.org
• Phone: 9739715597

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating a procedure for treating atrial functional mitral regurgitation

  This study looks at how well a new heart procedure works for people with atrial functional mitral regurgitation to see if it helps improve their health.

  Recruiting at 22 sites University Hospital of Cologne · The Bronx, New York and 21 other locations · NCT06911099

• Assessing risks and outcomes in patients with mitral regurgitation

  This study looks at patients with moderate to severe mitral regurgitation to see what factors might affect their health outcomes and help doctors make better treatment decisions.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT06876883

• Evaluation of the AltaValve System for treating mitral regurgitation

  This study is testing a new device called the AltaValve System to see if it can help people with mitral regurgitation who can't have surgery feel better and improve their heart function.

  Recruiting at 58 sites 4C Medical Technologies, Inc. · Phoenix, Arizona and 57 other locations · NCT06465745

• Using lung ultrasound to improve outcomes in cardiac surgery patients

  This study is testing if using lung ultrasound can help doctors find lung problems earlier in patients after heart surgery compared to regular X-rays and CT scans.

  Recruiting Saint Petersburg State University, Russia · Saint Petersburg, Sankt-Peterburg · NCT06377449

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.