Examining platelet structure in ischemic stroke patients before and after antiplatelet treatment
Official title: Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT05004233 · Data updated 2026-11-12
This study is testing how antiplatelet treatment affects the structure of blood platelets in patients who have had an ischemic stroke to see if it can help prevent future strokes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | December 13, 2024 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | August 7, 2025 |
| Trial ID | NCT05004233 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients hospitalized for non-cardioembolic ischemic stroke who require antiplatelet therapy.
✕Probably not a fit
Patients with contraindications to antiplatelet agents will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study aims to analyze the ultrastructural characteristics of platelets using transmission electron microscopy in patients hospitalized for ischemic stroke before and after starting antiplatelet therapy. The study will collect blood samples to assess platelet activation and its correlation with treatment efficacy. By identifying specific ultrastructural criteria, the research seeks to enhance clinical decision-making regarding antiplatelet strategies and potentially reduce the risk of recurrent ischemic strokes. The study focuses on patients with non-cardioembolic ischemic strokes requiring antiplatelet treatment as per standard guidelines.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing recurrent ischemic strokes through better monitoring of antiplatelet therapy.
How similar studies have gone: While the use of transmission electron microscopy for platelet analysis is a novel approach, similar studies have shown promise in understanding platelet dysfunction in various conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Social security affiliation * Signed informed consent * patients hospitalized for an non cardioembolic ischemic stroke requiring the onset of an antiplatelet therapy according to the usual guidelines recommendations Exclusion Criteria: Contraindications regarding antiplatelet agent(s) and/or at least one excipient according to Summary of Product Characteristics (SPC).
Where it's running
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Centre Hospitalier Universitaire de St-Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: Pierre Garnier, Md — Chu de Saint-Etienne
- Study coordinator: Pierre Garnier, Md
- Email: pierre.garnier@chu-st-etienne.fr
- Phone: (0)477127805
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.