Examining platelet structure in ischemic stroke patients before and after antiplatelet treatment
Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent
This study is testing how antiplatelet treatment affects the structure of blood platelets in patients who have had an ischemic stroke to see if it can help prevent future strokes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT05004233 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to analyze the ultrastructural characteristics of platelets using transmission electron microscopy in patients hospitalized for ischemic stroke before and after starting antiplatelet therapy. The study will collect blood samples to assess platelet activation and its correlation with treatment efficacy. By identifying specific ultrastructural criteria, the research seeks to enhance clinical decision-making regarding antiplatelet strategies and potentially reduce the risk of recurrent ischemic strokes. The study focuses on patients with non-cardioembolic ischemic strokes requiring antiplatelet treatment as per standard guidelines.
Who should consider this trial
Good fit: Ideal candidates are patients hospitalized for non-cardioembolic ischemic stroke who require antiplatelet therapy.
Not a fit: Patients with contraindications to antiplatelet agents will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing recurrent ischemic strokes through better monitoring of antiplatelet therapy.
How similar studies have performed: While the use of transmission electron microscopy for platelet analysis is a novel approach, similar studies have shown promise in understanding platelet dysfunction in various conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Social security affiliation * Signed informed consent * patients hospitalized for an non cardioembolic ischemic stroke requiring the onset of an antiplatelet therapy according to the usual guidelines recommendations Exclusion Criteria: Contraindications regarding antiplatelet agent(s) and/or at least one excipient according to Summary of Product Characteristics (SPC).
Where this trial is running
Saint-Etienne
- Centre Hospitalier Universitaire de St-Etienne — Saint-Etienne, France (Recruiting)
Study contacts
- Principal investigator: Pierre Garnier, Md — Chu de Saint-Etienne
- Study coordinator: Pierre Garnier, Md
- Email: pierre.garnier@chu-st-etienne.fr
- Phone: (0)477127805
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.