Examining Peripheral Arterial Disease in Cancer Patients Undergoing Surgery
Impact and Prevalence of PAD on Cancer Patients at High-risk for PAD Going to Surgery
This study looks at how common peripheral arterial disease is in older cancer patients who are having major surgeries and checks for differences in diagnosis among different racial groups.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05754944 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the prevalence of peripheral arterial disease (PAD) among cancer patients who have risk factors for blood circulation issues. Researchers aim to determine how common PAD is in this population and to assess differences in diagnosis rates across various racial groups. Participants will undergo assessments including ankle-brachial index (ABI) and toe-brachial index (TBI) tests, along with questionnaires to gather relevant health information. The study focuses on patients aged 65 and older who are scheduled for major surgeries.
Who should consider this trial
Good fit: Ideal candidates are cancer patients aged 65 and older with a history of diabetes or smoking, scheduled for major surgery.
Not a fit: Patients who are non-ambulatory, have a life expectancy of less than six months, or are in hospice care may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and management of PAD in cancer patients, potentially enhancing treatment outcomes.
How similar studies have performed: While the approach of studying PAD in cancer patients is relatively novel, similar studies have shown the importance of assessing vascular health in chronic disease populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cancer patients who are ≥ 65 years old * Either diabetes (on medication or insulin) or smoking history (current smoker, smoking within the last 15 years, ≥ 20 pack years) * Patients who are scheduled for major head and neck, thoracic, abdominal, or pelvic surgery requiring at least a 2-day admission * Ambulatory * ≥ 6 month life expectancy as determined based on clinical judgement by the treating physician. If treating clinician does not confirm life-expectancy ≥ 6 months, will calculate Lee Schoenberg Index using ePrognosis.ucsf.edu. Exclusion Criteria: * Hospice patient, patient with a DNR order * Non-ambulatory, wheelchair/bed bound * \< 6 month life expectancy based on the clinical judgement by the treating physician
Where this trial is running
New York, New York
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Yolanda Bryce, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Yolanda Bryce, MD
- Email: brycey@mskcc.org
- Phone: 212-639-6530
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.