Examining neuromuscular and metabolic changes as people age
Neuromuscular Impairment in Aging: a Longitudinal Study of Structural and Functional Mechanistic Bases of Age-related Alterations
This study looks at how aging affects muscle control and strength in people over 50 to see how it impacts their movement and quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 55 Years to 80 Years |
| Sex | All |
| Sponsor | University of Pavia Academic / other |
| Locations | 1 site (Pavia, Lombardia) |
| Trial ID | NCT06168591 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the decline in neuromuscular control and muscle mass associated with aging, focusing on how these changes affect mobility and overall quality of life. It aims to understand the non-linear progression of these age-related changes, particularly after the age of 50, and how factors like physical activity may influence outcomes. Participants will undergo various assessments to evaluate cognitive and physical performance, providing insights into the relationship between aging and neuromuscular function.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling older adults aged 50 and above who are cognitively unimpaired and have good mobility.
Not a fit: Patients with neurological disorders, diabetes, severe chronic illnesses, or significant mobility impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for maintaining mobility and independence in older adults.
How similar studies have performed: Other studies have shown success in understanding age-related changes in muscle function, but this study's longitudinal approach may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Community dwelling, mobility and cognitively unimpaired participants will be enrolled. Cognitive assessment: Mini Mental Status Examination (MMSE, cutoff: 24). Physical performance assessments: gait speed over 4-m (WS, \>0,8 m/s), Short Physical Performance Battery (SPPB, \>9), the Timed-Up and Go test (TUG \<20) and grip strength (GRIP, \>27 kg (M) or \>16 kg (F)). Exclusion Criteria: Parkinson's disease or other neurological disorder; diabetes; stroke; late-stage cancer; chronic kidney disease (IV and V stages); severe liver insufficiency; severe cardiac disorder and major recent heart surgery; severe osteoarthritis.
Where this trial is running
Pavia, Lombardia
- University of Pavia — Pavia, Lombardia, Italy (Recruiting)
Study contacts
- Study coordinator: Simone Porcelli, MD, PhD
- Email: simone.porcelli@unipv.it
- Phone: +3903289875
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.