Examining muscle growth in infants and young children with spastic cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the macroscopic muscle changes in infants and young children diagnosed with spastic cerebral palsy (SCP) using 3D freehand ultrasound. It will track the onset and progression of muscle alterations in relation to brain lesions, neuromuscular impairments, and treatment over time. By comparing these changes to typically developing children, the study seeks to identify patterns that could inform treatment protocols and improve functional outcomes for children with SCP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis of spastic cerebral palsy or patients at high-risk for spastic cerebral palsy
* Suspected GMFCS levels I-III (GMFCS = Gross Motor Function Classification Scale, expressing the overall functional level of impairment)

Exclusion Criteria:

* Non-ambulatory
* Botulinum neurotoxin type-A injections six months prior to enrollment
* Lower limb surgery two years prior to enrollment
* Muscle surgery at the muscles in the lower limb
* Selective dorsal rhizotomy as treatment history
* Presence of ataxia or dystonia
* Severe co-morbidities (severe epilepsy, severe behavior problems that impede the cooperation)

Where it's running

• UZ Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Kaat Desloovere, Prof. dr. — Department of Rehabilitation Sciences, KU Leuven, Belgium
• Study coordinator: Nathalie De Beukelaer
• Email: Nathalie.debeukelaer@kuleuven.be
• Phone: +3216341016

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.