Examining muscle characteristics in colorectal cancer patients with cachexia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the structural characteristics of trunk and limb muscles in cachectic colorectal cancer patients compared to non-cachectic patients and healthy controls. The study will involve taking minimal invasive fine needle muscle biopsies from the m. erector spinae and m. vastus lateralis muscles. A total of 60 participants will be recruited, including 10 cachectic patients, 25 non-cachectic patients, and 25 healthy controls, with measurements taken at a single time point to evaluate muscle characteristics and their implications in cancer cachexia.

Why it matters

Who can join: the full rules

Cachectic colorectal cancer patients.

Inclusion criteria:

* minimum age of 18 years old
* unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia
* Cachexia staging score (CSS): 5-12

Exclusion Criteria:

* Mental of psychological condition
* Insufficient knowledge of the Dutch language
* Muscle diseases affecting the spine and lower limbs
* Bedridden

Non-Cachectic cancer patients.

Inclusion criteria:

* minimum age of 18 years old
* No unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia
* Cachexia staging score (CSS): 0-2

Exclusion criteria:

* Mental of psychological condition
* Insufficient knowledge of the Dutch language
* Muscle diseases affecting the spine and lower limbs
* Bedridden

Healthy controls.

Inclusion criteria:

\- minimum age of 18 years old

Exclusion criteria:

* Mental of psychological condition
* Insufficient knowledge of the Dutch language
* Muscle diseases affecting the spine and lower limbs
* Bedridden

Where it's running

• Hasselt University - REVAL research institution
  Diepenbeek, Limburg, Belgium Recruiting
• Jessa Hospital
  Hasselt, Limburg, Belgium Recruiting

Study contacts

• Principal investigator: Kenneth Verboven, Professor — Hasselt University - REVAL
• Study coordinator: Britt van de Haterd, PhD student
• Email: britt.vandehaterd@uhasselt.be
• Phone: 0032479871509

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.