Examining Mitochondria in Heart Cells of Heart Failure Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the ultrastructural characteristics of mitochondria in cardiomyocytes from patients with chronic heart failure (CHF) and coronary artery disease. It will focus on understanding how mitochondrial dysfunction relates to the clinical progression of CHF, particularly in patients undergoing coronary artery bypass grafting. The study will involve a cohort of 45 to 60 patients, analyzing mitochondrial features through advanced imaging techniques. By correlating structural changes with clinical outcomes, the research seeks to clarify the role of mitochondrial health in heart failure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The presence of HFrEF or HFmrEF (EF of LV \<50%)
2. Obstructive multivessel coronary atherosclerosis as an indication for cardiac surgical correction of coronary blood flow (coronary bypass surgery)
3. Signed informed consent to participate in the study, separate consents for biomaterial sampling and genetic research

Exclusion Criteria:

1. Refusal of revascularization or participation in the study
2. Additional cardiac surgery other than coronary bypass surgery (valves, aneurysm)
3. Oncological diseases in the active stage;
4. The presence of implanted devices (EX, AICD, CT);
5. Severe renal dysfunction (GFR \<30 ml/min/1.73 m2);
6. Infiltrative heart diseases (sarcoidosis, amyloidosis, accumulation diseases);
7. Autoimmune diseases;
8. Acute infectious and exacerbations of chronic somatic diseases
9. Type 1 or type 2 diabetes mellitus
10. Contraindications to myocardial scintigraphy, cardiopulmonary stress test
11. Impossibility of prescribing optimal drug therapy after cardiac surgery

Where it's running

• Tomsk National Research Medical Center, Russian Academy of Sciences
  Tomsk, Russia Recruiting

Study contacts

• Principal investigator: Alla A Garganeeva, Ph.D. — Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
• Study coordinator: Elena A Kuzheleva, Ph.D.
• Email: kea@cardio-tomsk.ru
• Phone: +79234010502

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.