Examining miRNA Signatures in Glioma for Clinical Use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of three specific miRNAs on glioma biology, focusing on their roles in cell viability, proliferation, migration, and invasion. Researchers will utilize gain/loss of function strategies with primary glioma cells from patients with different IDH statuses. The study aims to understand how these miRNAs affect treatment responses, particularly to radiotherapy and temozolomide, in glioma patients. The research will be based on well-characterized glioma cell lines and surgical tissue samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* histological diagnosis of glioma;
* no concomitant primary tumor;
* no metastatic disease;
* availability of surgical material/tissue;
* written informed consent.

Exclusion Criteria:

* histological diagnosis of non-glial tumor;
* patients with concomitant other solid tumors;
* metastatic disease;
* no surgical material/tissue available;
* HIV seropositivity.

Where it's running

• "Regina Elena" National Cancer Institute
  Rome, Rome, Italy Recruiting

Study contacts

• Study coordinator: Ana Belen Diaz, Doctor
• Email: anabelen.diaz@ifo.it
• Phone: 06-52662522

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.