Examining megakaryocytes in patients with sickle cell disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the role of megakaryocytes, the precursors of platelets, in patients with sickle cell disease (SCD). It focuses on understanding how these cells behave in both steady states and during acute complications such as vaso-occlusive crises and acute chest syndrome. By analyzing the phenotypic and transcriptomic characteristics of megakaryocytes, the study seeks to uncover their involvement in the inflammatory and thrombotic processes associated with SCD. The research is conducted at the University Hospital in Toulouse, where patients will be monitored for their megakaryocyte activity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Sickle cell disease SS or S-béta° thalassemia
* Patient at steady state since at least 1 year or at steady state (without crisis), or during vaso-occlusive crisis or during acute chest syndrome
* Age \> 18 years old

Exclusion Criteria:

* Patient objects to take part in the study Hematologic disorder (leukemia, myeloma, myelodysplasic syndrome, myeloproliferative syndrome)
* Immune thrombocytopenia, Immunosuppressive or anti-inflammatory (biotherapies, corticosteroids, non steroidal anti-inflammatories drugs) Page 12 sur 23
* Anti-platelets agents
* Red blood cell exchange or transfusion \< 3 months

Where it's running

• CHU de Toulouse
  Toulouse, France, France Recruiting

Study contacts

• Principal investigator: Pierre COUGOUL, MD — University Hospital, Toulouse
• Study coordinator: Pierre COUGOUL, MD
• Email: cougoul.pierre@iuct-oncopole.fr
• Phone: 0531156265

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.