Examining markers related to tissue changes around dental implants
Expression of Epithelial-Mesenchymal Transition (EMT) Associated Markers in Peri-implant Tissues From Peri-implantitis Patients: A Case-Control Study
This study is testing how certain markers in the tissues around dental implants affected by inflammation can help us understand the changes happening there in people with peri-implantitis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Baghdad Academic / other |
| Locations | 1 site (Karbala) |
| Trial ID | NCT05832541 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the expression of epithelial-mesenchymal transition (EMT) markers in peri-implant tissues affected by peri-implantitis, a condition characterized by inflammation and bone loss around dental implants. It aims to understand how specific bacteria and cytokines contribute to the EMT process, which may affect the integrity of epithelial barriers. The study includes adult patients with diagnosed peri-implantitis and a control group with adjacent missing teeth, focusing on the relationship between inflammation and cellular changes in the affected tissues.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with at least one dental implant diagnosed with peri-implantitis or those with adjacent missing teeth suitable for implant placement.
Not a fit: Patients without dental implants or those not exhibiting signs of peri-implantitis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of peri-implantitis, potentially enhancing treatment outcomes for patients with dental implants.
How similar studies have performed: While the specific approach of examining EMT markers in peri-implantitis is novel, related studies have shown the importance of inflammatory processes in similar conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * For test group: adult patient age ≥18 years old presented having at least one dental implant with the following criteria for test group 1: (a) be in function for \>12 months; (b) clinically diagnosed as peri-implantitis with probing pocket depth ≥ 6 mm, bleeding on probing and/or suppuration; (c) presence of radiographic bone loss when compared to previous radiographs or with bone loss ≥ 3 mm apical to the 1st thread of the fixture; (d) presence of visual signs of inflammation. * For the control group: adult patient age ≥18 years old presented with: (a) one or more adjacent missing teeth in the posterior maxilla or mandible (positions premolar to molar); (b) adequate bone quality and availability for an implant placement of 4.5- 5.0 mm diameter and 8.5-13 mm length; (c) keratinized mucosa (KT) width of at least 3 mm. for both groups the patients give written consent to participate and attend the planned follow-up visits Exclusion Criteria: * For the test group: the exclusion criteria will be as follows: (a) patients with a history of chronic diseases such as diabetes mellitus; (b) currently smokers; (c) pregnant or lactating women; (d) patients who received peri-implant surgical therapy within 6 months before sampling; (e) patients who received antimicrobial therapy (systemic or local) within 3 months before sampling. * For the control group: the exclusion criteria will be as follows: (a) medical condition contraindicating implant surgery; (b) local inflammation (including untreated periodontitis); (c) post-extraction sites with less than 6 weeks of healing; (d) persistent intraoral infection; (e) absence of keratinized tissue; (f) history of chronic diseases such as diabetes mellitus; (g) currently a smoker and former smoker
Where this trial is running
Karbala
- Talib A. Alnajaty — Karbala, Iraq (Recruiting)
Study contacts
- Principal investigator: Talib A Alnajaty — University of Baghdad
- Study coordinator: Talib A Alnajaty
- Email: taleb.ali1105a@codental.uobaghdad.edu.iq
- Phone: 009647707905702
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.