Examining how exercise affects blood vessel health in people with mental health disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the impact of oxidants on blood vessel function in individuals with mental health disorders, specifically PTSD and GAD, as well as healthy individuals. The study consists of three sessions over two weeks, where participants will undergo various tests to assess their vascular health. In two of the sessions, participants will receive either antioxidant or placebo pills to evaluate the effects on their blood vessels. The goal is to better understand the relationship between mental health and cardiovascular function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease
* for PTSD group, a score of ≥ 33 on PCL-5 checklist
* for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist
* for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist

Exclusion Criteria:

* taking medications that could influence cardiovascular function
* current smokers who have recently quit smoking
* illicit drug use or excessive alcohol consumption
* pregnant women
* significant calorie restriction or vitamin/mineral deficiencies
* limited English proficiency

Where it's running

• Virginia Commonwealth University
  Richmond, Virginia, United States Recruiting

Study contacts

• Principal investigator: Ryan Garten, PhD — Virginia Commonwealth University
• Study coordinator: Ryan Garten, PhD
• Email: rsgarten@vcu.edu
• Phone: (804) 828-1948

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.