Examining how exercise affects blood vessel function in people with mental health disorders
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2
NA · Virginia Commonwealth University · NCT04922762
This study is testing how different types of exercise can improve blood vessel health in people with mental health disorders like PTSD and anxiety, while also looking at the effects of antioxidant pills.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 360 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Virginia Commonwealth University (other) |
| Locations | 1 site (Richmond, Virginia) |
| Trial ID | NCT04922762 on ClinicalTrials.gov |
What this trial studies
This research investigates the impact of different exercise training regimens on vascular function in individuals with mental health disorders, specifically PTSD and GAD, as well as healthy controls. Participants will undergo a series of testing sessions to assess their vascular health and will be randomly assigned to receive either antioxidant or placebo pills during specific visits. The study includes ten weeks of exercise training with varying intensities and volumes, conducted over five sessions. The goal is to determine how exercise and oxidant levels influence blood vessel health in these populations.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with PTSD or GAD, as well as healthy individuals without cardiovascular issues.
Not a fit: Patients with significant cardiovascular, pulmonary, or metabolic diseases, or those on medications affecting cardiovascular function, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise recommendations for individuals with mental health disorders, enhancing their vascular health and overall well-being.
How similar studies have performed: Other studies have shown promising results in the relationship between exercise and vascular health, particularly in populations with mental health disorders, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease * for PTSD group, a score of ≥ 33 on PCL-5 checklist * for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist * for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist Exclusion Criteria: * taking medications that could influence cardiovascular function * current smokers who have recently quit smoking * illicit drug use or excessive alcohol consumption * pregnant women * significant calorie restriction or vitamin/mineral deficiencies * limited English proficiency
Where this trial is running
Richmond, Virginia
- Virginia Commonwealth University — Richmond, Virginia, United States (RECRUITING)
Study contacts
- Principal investigator: Ryan Garten, PhD — Virginia Commonwealth University
- Study coordinator: Ryan Garten, PhD
- Email: rsgarten@vcu.edu
- Phone: (804) 828-1948
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Peripheral Vascular Diseases, cardiovascular disease, vascular function, PTSD, GAD, Oxidant