Examining how exercise affects blood vessel function in people with mental health disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research examines the impact of different exercise training programs on vascular function in individuals with mental health disorders, specifically PTSD and GAD, as well as healthy individuals. The study involves multiple testing sessions over approximately 14 weeks, including initial assessments of body measures and blood vessel health, followed by a ten-week exercise training program. Participants will be randomly assigned to receive either antioxidant or placebo pills during specific testing sessions to evaluate their effects on vascular health. The study aims to understand how exercise and oxidants influence blood vessel function in these populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease
* for PTSD group, a score of ≥ 33 on PCL-5 checklist
* for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist
* for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist

Exclusion Criteria:

* taking medications that could influence cardiovascular function
* current smokers who have recently quit smoking
* illicit drug use or excessive alcohol consumption
* pregnant women
* significant calorie restriction or vitamin/mineral deficiencies
* limited English proficiency

Where it's running

• Virginia Commonwealth University
  Richmond, Virginia, United States Recruiting

Study contacts

• Principal investigator: Ryan Garten, PhD — Virginia Commonwealth University
• Study coordinator: Ryan Garten, PhD
• Email: rsgarten@vcu.edu
• Phone: (804) 828-1948

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.