Examining how exenatide works in pregnant women with gestational diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the pharmacokinetics and pharmacodynamics of exenatide, a drug approved for type II diabetes, in pregnant women diagnosed with gestational diabetes. The research aims to understand how the body processes exenatide and its effectiveness in stimulating insulin secretion and controlling blood sugar levels after meals. Currently, there are limited treatment options for gestational diabetes, and this study seeks to explore a potential alternative therapy that may improve blood sugar management for affected women.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant women (singleton)
* Gestational diabetes not requiring medical therapy
* Between 18 and 50 years of age
* Able to give written informed consent

Exclusion Criteria:

* Women in the first trimester of pregnancy
* Hematocrit less than 30%
* Current or past treatment with any hypoglycemic agent
* Women with gastrointestinal disease or symptoms consistent with nausea, vomiting, abdominal pain or reflux requiring medical treatment.
* Women with high triglyceride levels, history of gallbladder or pancreatic disease.
* Clinical diagnosis or history of any renal insufficiency (or decreased creatinine clearance)

Where it's running

• Magee Womens Hospital of UPMC
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Maisa Feghali, MD — University of Pittsburgh
• Study coordinator: Maisa Feghali, MD
• Email: feghalim@upmc.edu
• Phone: 412 647 1000

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Mobile-based obstetric monitoring for hypertension and diabetes during pregnancy

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.