Examining HDL and inflammation in diabetes and obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the role of high-density lipoprotein (HDL) and its enzyme paraoxonase 1 (PON1) in patients with diabetes and obesity, particularly those scheduled for bariatric surgery. It aims to understand how inflammation and visceral fat affect HDL functionality and PON1 activity, which are crucial for cardiovascular health. The study will assess patients before and after bariatric surgery to evaluate changes in HDL properties and related physiological parameters. By focusing on both Type 1 and Type 2 diabetes patients, the research seeks to uncover potential links between weight loss and improvements in cardiovascular risk factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with Type 1 diabetes who are not receiving lipid-lowering drugs, omega fatty acid supplements or thiazolidinediones and without clinical and/or ECG evidence of CHD.

Type 2 diabetic patients who are not receiving omega fatty acid supplements or thiazolidinediones and without clinical and/or ECG evidence of CHD.

Patients with impaired fasting glucose undergoing oral glucose tolerance test. Patients scheduled for bariatric surgery. Healthy controls who have no major acute or chronic illness, are not receiving regular medication and not taking omega fatty acid supplements, do not have clinically overt ischaemic heart disease.

Subjects (male and female) aged between 20 and 75. Subjects who have capacity and understanding for informed consent process.

Exclusion Criteria:

* Type 1 diabetics using lipid lowering therapy, thiazolidinediones, omega fatty acid supplements. History and/or ECG evidence of ST segment changes indicative of CHD.

Type 2 diabetics receiving thiazolidinediones, omega fatty acid supplements. History and/or ECG evidence of ST segment changes indicative of CHD.

Healthy controls who have any history of CHD, vascular insufficiency, or diabetes. Use of any lipid-lowering drug or omega fatty acid supplements.

Where it's running

• Central Manchester University Hospitals NHS Foundatioon Trust
  Manchester, Lancashire, United Kingdom Recruiting

Study contacts

• Principal investigator: Handrean Soran, MD FRCP — Manchester University NHS Foundation Trust
• Study coordinator: Handrean Soran, MD FRCP
• Email: hsoran@aol.com
• Phone: 01612764843

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.