Examining fungal infections in heart transplant patients
Multicenter Retrospective Cohort Study on Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients
University Hospital, Strasbourg, France · NCT06498310
This study looks at how often heart transplant patients get serious fungal infections and what factors might increase their risk, to help improve treatment for these patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France (other) |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT06498310 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the incidence and risk factors of invasive fungal infections caused by filamentous fungi in heart transplant patients. It aims to gather recent data from patients who experienced these infections between January 1, 2008, and December 31, 2022. By analyzing the collected data, the study seeks to improve the management and treatment of these serious infections in immunocompromised individuals. The study will utilize established criteria to confirm the presence of infections and will include adult heart transplant recipients.
Who should consider this trial
Good fit: Ideal candidates for this study are adult heart transplant patients who have experienced invasive fungal infections with filamentous fungi.
Not a fit: Patients who have not undergone heart transplantation or who have expressed opposition to the reuse of their data will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and management of invasive fungal infections in heart transplant patients, potentially improving patient outcomes.
How similar studies have performed: While there is limited recent data specifically on heart transplant patients, similar studies on invasive fungal infections in other immunocompromised populations have shown the importance of understanding incidence and risk factors.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient ≥18 years old * Heart transplant * Invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022 * Proven or probable infection with filamentous fungi according to EORTC/MSGERC criteria (20): * Invasive aspergillosis * Mucormycosis * Fusarium wilt * Scedosporiosis * Other filamentous fungus infection * Subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research. Exclusion Criteria: * Patient having expressed his opposition to participating in the study * Patient not having a liver transplant * Subject under guardianship, curatorship or safeguard of justice.
Where this trial is running
Strasbourg
- Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France — Strasbourg, France (RECRUITING)
Study contacts
- Study coordinator: François DANION, MD
- Email: francois.danion@chru-strasbourg.fr
- Phone: 33 3 69 55 15 88
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Invasive Fungal Infections, Filamentous fungi, Heart transplant, Fungal infections