Examining EEG Patterns and Delirium in Elderly Patients After Surgery
The Second Affiliated Hospital of Nanchang University
This study looks at how brain activity measured by EEG before and after surgery might be linked to confusion in older patients after major gastrointestinal surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 65 Years to 80 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital of Nanchang University Academic / other |
| Locations | 1 site (Jiangxi, NanChang) |
| Trial ID | NCT06082024 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between perioperative EEG characteristics and the occurrence of postoperative delirium in elderly patients undergoing major gastrointestinal surgery under general anesthesia. It will compare EEG data collected before and after surgery with the incidence of cognitive dysfunction in patients who experience delirium versus those who do not. The study seeks to identify potential mechanisms behind postoperative delirium and to evaluate clinical risk factors associated with it.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 and older who are scheduled for major abdominal surgery under general anesthesia.
Not a fit: Patients with serious heart and lung conditions, a history of mental illness, or recent cerebrovascular accidents may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction and management of postoperative delirium in elderly patients, enhancing their recovery and cognitive outcomes.
How similar studies have performed: While the correlation between EEG features and cognitive outcomes has been explored, this specific approach focusing on elderly surgical patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Education level in primary school or above; 2. Age ≥65 years old, gender is not limited; 3. Good communication ability, language expression ability, mental state and consciousness state; 4. Preoperative simple mental state scale score ≥27 points; 5. no history of craniocerebral diseases; 6. For patients who plan to choose abdominal surgery under general anesthesia, the operation time is expected to be about 2h-4h; 7. ASA anesthesia grade I \~ III; 8. No general anesthesia contraindications; 9. Sign informed consent voluntarily; Exclusion Criteria: 1. Relative contraindications of general anesthesia: patients with serious heart and lung function diseases, drug allergy history, etc. 2. Patients with a history of mental illness or long-term psychiatric drugs (dementia, schizophrenia), chronic analgesic drug use history, alcoholism history and cognitive dysfunction; 3. any cerebrovascular accident occurred within 3 months, such as stroke, transient ischemic attack (TIA), etc. 4. Diabetic patients with severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy); 5. Chronic hypoxia and carbon dioxide storage, such as chronic obstructive emphysema; 6. a long history of alcohol abuse; 7. Unable to cooperate to complete the test, the patient or family rejected the participant.
Where this trial is running
Jiangxi, NanChang
- the Second Affiliated Hospital of Nanchang University, Nanchang University — Jiangxi, NanChang, China (Recruiting)
Study contacts
- Study coordinator: Fuzhou Hua
- Email: huafuzhou@126.com
- Phone: 15170238929
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.