Examining DNA Methylation's Role in Obesity and Vascular Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how DNA hypomethylation contributes to inflammation and vascular dysfunction in obese individuals, aiming to identify nonpharmacological interventions like aerobic exercise to mitigate these effects. It focuses on the relationship between obesity, epigenetic changes, and cardiovascular health, particularly how lifestyle factors can influence gene expression related to inflammation. By analyzing DNA from fat tissues, the study seeks to establish a link between hypomethylation and increased adipocytokine production, which may lead to vascular issues. The ultimate goal is to develop effective strategies for preventing obesity-related cardiovascular diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI ≥ 35 kg/m2
* Between ages 18-50 years
* Not pregnant
* Approved for a bariatric surgery

Exclusion Criteria:

* To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
* Pregnant women will be excluded, as they will not be eligible for bariatric surgery
* Current smokers
* Currently abusing alcohol or drugs

Where it's running

• University of Illinois at Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Abeer Mohamed, MD, PhD — University of Illinois Chicago
• Study coordinator: Abeer Mohamed, MD, PhD
• Email: amahmo4@uic.edu
• Phone: 3127539998

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.