Clinical trial Recruiting at 1 site Observational Ages 18 and up

Examining differences in cardiac surgery outcomes between men and women

Official title: SEx-specific Differences in Cardiac Surgery Patients (SECS). A Retrospective Registration and Evaluation of Characteristics and Perioperative Management of Cardiac Surgery Patients

Run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT06554925 · Data updated 2026-11-12

This study looks at how men and women experience cardiac surgery differently to see if there are specific factors that can help improve recovery for women.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment10000 (estimated)
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Academic / other
Locations1 site (Amsterdam, North Holland)
StatusRecruiting
StartedMarch 1, 2022
Main results expectedMarch 1, 2030
Study endsMarch 1, 2031
Registry record updatedAugust 15, 2024
Trial IDNCT06554925 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years who have undergone cardiac surgery at the specified institution.

Probably not a fit

Patients who have not undergone cardiac surgery or are under 18 years old may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the differences in perioperative factors between female and male patients undergoing cardiac surgery. It will analyze various parameters such as body weight adaptation, medical history, pharmacokinetics, and outcomes related to morbidity and mortality at short-term and long-term intervals. The study seeks to establish a database of these perioperative parameters to identify factors that may adversely affect recovery in females, with the goal of improving their surgical outcomes. By focusing on sex-specific differences, the research aims to enhance perioperative care pathways tailored for female patients.

Why it matters

Potential benefit: If successful, this study could lead to improved recovery and reduced complications for female patients undergoing cardiac surgery.

How similar studies have gone: While there have been studies on preoperative cardiovascular differences, this specific focus on female-specific perioperative care in cardiac surgery is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients \> 18 years
* All patients who underwent cardiac surgery from 1 January 1998 in the AUMC, location VUmc, until 1 June 2021.

Exclusion Criteria:

* None

Where it's running

  • Academic Medical Center
    Amsterdam, North Holland, Netherlands
    Recruiting

Study contacts

  • Principal investigator: Markus W Hollmann, Professor — Anesthesiology and Pain Medicine, Amsterdam Medical Center
  • Study coordinator: Jennifer S Breel, MSc
  • Email: j.s.breel@amsterdamumc.nl
  • Phone: +31610019257

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.