Examining changes in the lymphatic drainage system after brain hemorrhage
Radiological Changes of Glymphatic-meningeal Lymphatic Drainage System After Spontaneous Subarachnoid Hemorrhage
This study is trying to see how a brain bleed affects the drainage system that helps clear waste from the brain in people who have had a subarachnoid hemorrhage.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06444438 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the glymphatic-meningeal lymphatic drainage system in patients who have experienced a subarachnoid hemorrhage (SAH). It aims to understand how the influx of blood components into the cerebrospinal fluid circulation affects this drainage system and its role in complications such as cerebral edema and neuroinflammation. By utilizing advanced imaging techniques, the study seeks to provide clinical evidence of changes in the lymphatic drainage system post-SAH, which has only been previously confirmed in animal models.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18-80 who have experienced spontaneous subarachnoid hemorrhage and are undergoing aneurysm interventional therapy.
Not a fit: Patients with a history of trauma or prior brain injury, as well as those with significant comorbidities or missing imaging data, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of complications following subarachnoid hemorrhage, potentially enhancing patient outcomes.
How similar studies have performed: While this approach has shown promise in animal studies, clinical evidence in humans is currently lacking, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ①18-80 years old; ② Voluntary patients with spontaneous subarachnoid hemorrhage undergoing aneurysm interventional therapy. Exclusion Criteria: * ①A history of trauma or prior brain injury (stroke, cerebral hemorrhage, etc., leaving associated chronic changes on CT); ②Patients with imaging data loss and severe comorbidities prior to the onset of SAH
Where this trial is running
Hangzhou, Zhejiang
- the Second Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.