Examining brain blood flow changes in lacunar stroke patients after managing risk factors
Understanding the Relationship Between Controlling Risk Factors and Cerebral Haemodynamic Changes in Lacunar Stroke, and Its Interaction With Ageing
This study is testing how managing risk factors like high blood pressure and diabetes affects blood flow in the brains of people who have had a lacunar stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester, Leicestershire) |
| Trial ID | NCT06354881 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the differences in cerebral blood flow in patients diagnosed with lacunar stroke before and after the management of risk factors such as high blood pressure and diabetes. Participants will undergo a brain blood flow assessment using Transcranial Doppler Ultrasonography during sit-stand maneuvers at their initial appointment and again four weeks later. By comparing these assessments, the study seeks to understand how managing these risk factors impacts cerebral haemodynamics and potentially reduces the risk of further strokes or cognitive impairment.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-120 years with a diagnosis of lacunar stroke and either new or known hypertension and/or diabetes.
Not a fit: Patients who lack the capacity to perform the required maneuvers or have poorly controlled medical comorbidities affecting cerebral haemodynamics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with lacunar stroke, potentially reducing the risk of recurrent strokes and cognitive decline.
How similar studies have performed: While there have been studies on cerebral blood flow and stroke management, this specific approach focusing on lacunar stroke and risk factor management is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged between 18-120 years. * Diagnosis of lacunar stroke syndrome. * New diagnosis or known diagnosis of hypertension and/or diabetes. Exclusion Criteria: * Those who lack capacity can have a personal consultee consent to the study if they can still perform study requirements such as the sit-stand manoeuvre. Those who either cannot perform the manoeuvre or do not have a personal consultee to allow them to consent, are not able to take part. * Those with poorly controlled medical comorbidities affecting cerebral haemodynamics. (eg., heart failure).
Where this trial is running
Leicester, Leicestershire
- University Hospitals of Leicester NHS Trust — Leicester, Leicestershire, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Jatinder S Minhas, SFHEA
- Email: jm591@leicester.ac.uk
- Phone: +44 116 252 3299
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.