Examining brain blood flow changes in lacunar stroke patients after managing risk factors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the differences in cerebral blood flow in patients diagnosed with lacunar stroke before and after the management of risk factors such as high blood pressure and diabetes. Participants will undergo a brain blood flow assessment using Transcranial Doppler Ultrasonography during sit-stand maneuvers at their initial appointment and again four weeks later. By comparing these assessments, the study seeks to understand how managing these risk factors impacts cerebral haemodynamics and potentially reduces the risk of further strokes or cognitive impairment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged between 18-120 years.
* Diagnosis of lacunar stroke syndrome.
* New diagnosis or known diagnosis of hypertension and/or diabetes.

Exclusion Criteria:

* Those who lack capacity can have a personal consultee consent to the study if they can still perform study requirements such as the sit-stand manoeuvre. Those who either cannot perform the manoeuvre or do not have a personal consultee to allow them to consent, are not able to take part.
* Those with poorly controlled medical comorbidities affecting cerebral haemodynamics. (eg., heart failure).

Where it's running

• University Hospitals of Leicester NHS Trust
  Leicester, Leicestershire, United Kingdom Recruiting

Study contacts

• Study coordinator: Jatinder S Minhas, SFHEA
• Email: jm591@leicester.ac.uk
• Phone: +44 116 252 3299

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Polyphenol-rich Salicornia plus B vitamins to slow cognitive decline after lacunar stroke

  This will test whether a Salicornia-derived polyphenol supplement combined with B vitamins can slow thinking and memory decline in people who had a lacunar stroke within the past year.

  Recruiting Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · Seville · NCT07353424

• IV rt-PA versus two-antiplatelet drug combo (DAPT) for small (lacunar) ischemic stroke

  This trial will test whether a two-drug antiplatelet combination works as well as IV rt-PA and causes less bleeding for adults with a very small (lacunar) ischemic stroke treated within 4.5 hours.

  Recruiting at 29 sites Phase 4 Nippon Medical School · Chūō and 28 other locations · NCT07111559

• Telecoached exercise program to boost brain connectivity after small vessel (lacunar) stroke

  This program will test whether a 24-week, twice-weekly telecoached exercise plan can improve brain connectivity and physical fitness in people aged 60+ who had a lacunar stroke and are currently not very active.

  Recruiting University of L'Aquila · Avezzano, L'Aquila · NCT06525987

• Investigating retinal vessel leakage in cerebral small vessel disease

  This study is trying to see if leaking blood vessels in the eyes can help us understand how serious cerebral small vessel disease is in people who have had mild strokes.

  Recruiting University of Edinburgh · Edinburgh · NCT06416371

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.