Examining blood pressure variability in non-hypertensive patients with ischemic cerebrovascular disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on non-hypertensive patients diagnosed with ischemic cerebrovascular disease (ICVD), such as ischemic stroke or transient ischemic attack. Participants will undergo ambulatory 24-hour blood pressure monitoring at baseline and again one year later to assess blood pressure variability (BPV) and its relationship with vascular risk. The study aims to identify factors influencing BPV and explore how BPV may affect the risk of future vascular events in this patient population. Data will be collected through clinical assessments, imaging, and patient self-reports over a three-year follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging.
2. Less than 90 days after onset of ischemic stroke or TIA symptoms.
3. The blood pressure measured 5\~90 days after the ICVD onset without any anti-hypertension treatment is less than 140/90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement).
4. Consent to participate in the study.

Exclusion Criteria:

1. A definite diagnosis of hypertension.
2. Under anti-hypertension treatment.
3. Worsening neurological conditions.
4. With a National Institute of Health Stroke Scale score more than 5 points.
5. Intracranial hemorrhage.
6. Autonomic failure.
7. With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years.
8. With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline.
9. Mental disease.
10. Pregnant.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, Bj, China Recruiting

Study contacts

• Study coordinator: Xin Ma, MD, PhD
• Email: maxin118@hotmail.com
• Phone: 13501390691

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.