Examining blood pressure variability and frailty in older adults
Study on Blood Pressure Variability and Frailty in the Older People: the HypoPHrail Study
This study is trying to see how changes in blood pressure affect frailty in older adults with high blood pressure who are 75 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Ages | 75 Years and up |
| Sex | All |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT06868069 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between blood pressure variability and frailty in individuals aged 75 and older diagnosed with hypertension. It will utilize ambulatory blood pressure monitoring to identify hypotensive episodes and assess their association with adverse health outcomes such as hospitalization and cardiovascular events. Additionally, the study will explore how home blood pressure variability correlates with frailty and the prevalence of hypotensive phenotypes among frail hypertensive patients. The study is conducted at a single center and involves diagnostic tests and questionnaires.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 75 years and older with a diagnosis of hypertension.
Not a fit: Patients with a life expectancy of less than 6 months or those who refuse participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the understanding of blood pressure management in frail older adults, potentially leading to better health outcomes.
How similar studies have performed: While there have been studies on blood pressure variability, this specific focus on frailty in older adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 75 years * Diagnosis of hypertension according to the criteria of the European Society of Cardiology guidelines \[Williams 2018\] * Consent of the patient (or legal representative) to participate in the study Exclusion Criteria: * Refusal of the patient or his/her legal representative * Life expectancy of less than 6 months
Where this trial is running
Milan
- Istituto Auxologico Italiano IRCCS — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Alessandro Croce, MD
- Email: a.croce@auxologico.it
- Phone: +3902619111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.