Examining biomarkers in patients with acute cerebral hypoxia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational trial aims to investigate the levels of thrombo-inflammation biomarkers in patients experiencing acute cerebral hypoxia due to specific conditions such as ischemic stroke, subarachnoid hemorrhage, and intra-parenchymal hematoma. It compares these biomarker concentrations to those in a control group of patients without cerebral hypoxia. Additionally, the study will explore the relationship between biomarker levels and clinical outcomes in patients with cerebral hypoxia. Blood samples will be collected for analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- For cases, admitted within the first 36 hours of an acute neurological symptom related to :

* An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,
* A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,
* An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission \>4.

OR

* For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.
* Express consent to participate in the study.
* Member or beneficiary of a social security.

Exclusion Criteria:

* Pre-existing functional and/or cognitive disability
* Patient under legal protection.
* Pregnant or breastfeeding woman.
* Patient with secondary haemorrhagic transformation.

Secondary exclusion criteria :

* Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy.
* Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.).
* TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging.

Excluded patients will be replaced.

Where it's running

• Hôpital Fondation Adolphe de Rothschild
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: François DELVOYE
• Email: fdelvoye@for.paris
• Phone: 0148036556

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.