Examining biomarkers in children with asthma
Official title: The Role of Biomarkers in the Occurrence and Development of Asthma
Run by Children's Hospital of Chongqing Medical University · NCT05768399 · Data updated 2026-11-12
This study is testing if certain markers in the blood can help us understand how severe asthma is in children compared to healthy kids.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Years to 12 Years |
| Sex | All |
| Enrollment | 2 (estimated) |
| Sponsor | Children's Hospital of Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Status | Recruiting |
| Started | July 4, 2023 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | July 7, 2023 |
| Trial ID | NCT05768399 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 4-12 years with a diagnosis of asthma or recurrent episodes.
✕Probably not a fit
Patients with other respiratory diseases or significant comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the expression levels of biomarkers, specifically GITRL, in the peripheral blood of children diagnosed with asthma. It will compare these levels with those of healthy children to analyze their correlation with asthma severity. The study will recruit 30 children with asthma and 30 healthy controls, collecting blood samples and clinical data to assess the predictive value of biomarkers for asthma occurrence and development. The severity of asthma will be evaluated using spirometry and the C-CAT score.
Why it matters
Potential benefit: If successful, this study could provide new diagnostic and predictive tools for managing asthma in children.
How similar studies have gone: Other studies have shown promise in using biomarkers for asthma diagnosis and management, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * In line with the diagnostic criteria in the Guidelines for the Diagnosis and Prevention of Bronchial Asthma in Children (2016 Edition) * Age: 4-12 years old for new diagnosis or recurrent episodes * Typical clinical manifestations and complete clinical data * Family members or guardians of children with informed research and signed consent * All healthy control subjects had no history of lung disease, allergic rhinitis or any other atopic disease Exclusion Criteria: * Suffering from other respiratory diseases (such as bronchiectasis, allergic rhinitis, respiratory failure, tuberculosis, obstructive airway disease) or other inflammatory diseases. * Abnormal development of congenital airway and lung tissue * History of immunosuppressant or glucocorticoid use in the first 4 weeks * Suffering from other endocrine system and immune system diseases * Incomplete clinical data or examinations.
Where it's running
-
Shaoqing Zhang
Chongqing, Chongqing Municipality, China Recruiting
Study contacts
- Study coordinator: Ding Fengxia, PhD
- Email: dingfengxia305@163.com
- Phone: 86-15178712548
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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ASMact: Managing bronchial asthma attacks in children
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This study tests whether biomarkers from the lungs and blood can predict how asthma and protracted bacterial bronchitis in children will progress and respond to current therapies.
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Using technology and school–clinic coordination to improve asthma care for children.
This project will try a tech-enabled program plus school care coordination to help children ages 4–12 with persistent or uncontrolled asthma follow guideline-based treatment and have fewer symptoms and school problems.
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Boosting use of SMART inhaler therapy for children with moderate-to-severe asthma
This project will test whether adding community health workers and nurse care managers to electronic health record decision support and education helps children ages 5–18 with uncontrolled asthma use single maintenance and reliever therapy (SMART).
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.