Examining apraxia in Parkinson's patients with deep brain stimulation
Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation
This study is trying to see how deep brain stimulation affects movement difficulties in people with Parkinson's disease by testing their ability to perform tasks with the stimulation turned on and off.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT04725773 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to assess the prevalence of apraxia in patients with Parkinson's disease who have undergone deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus. It will evaluate the safety and feasibility of an apraxia testing protocol in these patients, comparing their performance in DBS ON and OFF states. The study will involve 60 participants who have had stable DBS for at least six months, focusing on limb-kinetic, ideomotor, and ideational apraxia. The findings will help lay the groundwork for larger studies exploring the relationship between DBS and apraxia.
Who should consider this trial
Good fit: Ideal candidates are Parkinson's disease patients aged 18 to 80 with chronic, stable DBS of the STN or GPi for at least six months.
Not a fit: Patients with other neurological disorders, poor manual dexterity unrelated to Parkinson's, or a diagnosis of PD dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how DBS affects apraxia in Parkinson's patients, potentially leading to improved treatment strategies.
How similar studies have performed: While studies on DBS and motor symptoms are common, the specific focus on apraxia in this context is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with PD as defined by the UK Brain Bank Criteria 2. Male or female, ages 18 to 80 years old 3. Chronically implanted DBS of either the STN or GPi for a minimum of 6 months Exclusion Criteria: 1. Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke) 2. History of previous neurosurgical intervention that was not DBS 3. Patients with DBS of targets other than the STN or GPi, or leads in both targets 4. Patients in whom there is poor manual dexterity for a reason other than PD (e.g. orthopedic injury, amputation) 5. Patients with a diagnosis of PD dementia
Where this trial is running
Gainesville, Florida
- UF Health at the University of Florida — Gainesville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Bhavana Patel, DO — University of Florida
- Study coordinator: Bhavana Patel, DO
- Email: Bhavana.Patel@neurology.ufl.edu
- Phone: (352) 294-5400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.